Bis-(dimethylamino)phenylphosphine

Base Information

• Chemical Name: Bis-(dimethylamino)phenylphosphine
• CAS No.: 6143-71-1
• Molecular Formula: C10H17N2P
• Molecular Weight: 196.232
• NSC Number: 300840
• DSSTox Substance ID: DTXSID30316207
• Nikkaji Number: J1.150.843J
• Wikidata: Q82069868
• Mol file: 6143-71-1.mol

Synonyms:6143-71-1;bis-(dimethylamino)phenylphosphine;NSC 300840;NSC300840;SCHEMBL4797776;Phenylbis(dimethylamino)phosphine;bis(dimethylamino)phenyl-phosphine;DTXSID30316207;NSC-300840;Phosphorous diamide, N,N,N',N'-tetramethyl-P-phenyl-

Chemical Property of Bis-(dimethylamino)phenylphosphine

Chemical Property:

• Boiling Point: 266.2°Cat760mmHg
• Flash Point: 114.8°C
• Density: g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 196.112935548
• Heavy Atom Count: 13
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)P(C1=CC=CC=C1)N(C)C

Technology Process of Bis-(dimethylamino)phenylphosphine

There total 7 articles about Bis-(dimethylamino)phenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Dichlorophenylphosphine (644-97-3) + dimethyl amine (124-40-3) → bis(dimethylamino)phenyl phosphine (6143-71-1)

Guidance literature:

In diethyl ether; at 0 ℃; for 2h;

DOI:10.1021/ol0481840

Reference yield: 83.0%

bis(N,N-dimethylamino)chlorophosphine (3348-44-5) + phenylmagnesium bromide → bis(dimethylamino)phenyl phosphine (6143-71-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1002/1521-3773(20000602)39:11<1946::AID-ANIE1946>3.0.CO;2-I

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + bis(N,N-dimethylamino)chlorophosphine (3348-44-5) → bis(dimethylamino)phenyl phosphine (6143-71-1)

Guidance literature:

bromobenzene; With n-butyllithium; In Petroleum ether; at -78 - 55 ℃; for 1.5h; Inert atmosphere; Schlenk technique;

bis(N,N-dimethylamino)chlorophosphine; In Petroleum ether; at 20 - 50 ℃; for 5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.inorgchem.1c01790

upstream raw materials:

bis(N,N-dimethylamino)chlorophosphine

phenyllithium

Dichlorophenylphosphine

dimethyl amine

Downstream raw materials:

5-phenyl-1,6-dioxa-4,9-diaza-5λ⁵-phospha-spiro[4.4]nonane

5-phenyl-1,4,6,9-tetraoxa-5-phosphaspiro<4.4>nonane

2-phenyl-[1,3,2]dioxaphospholane

3,3,8,8-tetramethyl-5-phenyl-1,6-dioxa-4,9-diaza-5λ⁵-phospha-spiro[4.4]nonane