614750-82-2

Usage

Uses

Used in Pharmaceutical Development:
Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylis utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential therapeutic benefits, making it an important component in the ongoing pursuit of novel medical treatments.
Used in Agrochemical Research:
In the agrochemical industry, Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl- serves as a building block for the development of new pesticides and other agricultural chemicals. Its properties may contribute to the creation of more effective and environmentally friendly products, addressing the needs of modern agriculture.
Used in Chemical Synthesis:
Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylis employed as a versatile reactant in chemical synthesis processes. Its reactivity and structural attributes make it suitable for the production of a wide range of chemical products, from specialty chemicals to advanced materials.
Used in Drug Discovery:
Ethanone, 1-(6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylis also used in drug discovery initiatives, where its unique properties are leveraged to identify and develop new therapeutic agents. Its potential role in this field underscores the importance of exploring novel chemical structures in the quest for innovative medicines.

InChI:InChI=1S/C14H12N4O/c1-10-3-2-4-12(17-10)13(19)7-11-5-6-14-15-9-16-18(14)8-11/h2-6,8-9H,7H2,1H3

Upstream product

• 614750-85-5 diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate 
• 614750-81-1 [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 

Downstream Products

• 356560-84-4 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione 
• 1352609-09-6 N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline 
• 1352609-64-3 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-4-((dimethylamino)methyl)benzonitrile 
• 1352609-77-8 N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoro-N-methylaniline 
• 1352610-23-1 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile 
• 1352610-24-2 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzamide 
• 1352609-89-2 6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine 
• 1352609-91-6 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde 
• 1352610-22-0 N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline sulfate 
• 1415663-86-3 C₂₃H₁₇F₃N₆OS 
• 1383123-98-5 3-[[[4-(6-methyl-2-pyridinyl)-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-2-thiazolyl]amino]methyl]benzonitrile 
• 1415663-87-4 C₂₂H₁₇FN₆S 
• 1415663-88-5 C₂₂H₁₇ClN₆S 
• 1415663-89-6 C₂₃H₂₀N₆S 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin- 2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4] triazolo[1,5-a]pyridin-6-yl)thiazoles 12a-ab, 13a, 13b, and 18a-d has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The N-(3-fluorobenzyl)-4-(6- methylpyridin-2-yl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiazol-2-amine (12b) inhibited ALK5 phosphorylation with an IC50 value of 7.01 nM and showed 61% inhibition at 30 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct.

2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors

This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4triazolo[1,5- apyridin-6-yl)pyrazoles 14a-ae, 16a, 16b, and 21a-c has been prepared and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter ass

Tri-substituted heteroaryls and methods of making and using the same

Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).