6148-33-0

Upstream product

• 64-17-5 ethanol 
• 141-97-9 ethyl acetoacetate 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 116-09-6 hydroxy-2-propanone 
• 78-95-5 chloroacetone 
• 122552-44-7 2-Bromo-3-methoxy-3-prop-2-ynyloxy-butyric acid ethyl ester 
• 35044-52-1 ethyl 2-acetyl-3-methylbut-2-enoate 
• 1609547-45-6 ethyl 2,4-dimethyl-4,5-dihydrofuran-3-carboxylate 
• 15301-37-8 3-ethoxycarbonyl-3-penten-2-one 
• 141764-75-2 2-Acetyl-4-benzenesulfinyl-3-methyl-butyric acid ethyl ester 
• 692-72-8 3-acetoxy-2-chloroprop-1-ene 
• 627-09-8 Propargyl acetate 
• 96-11-7 1,2,3-tribromopropane 
• 96-18-4 1,2,3-trichloropropane 

Downstream Products

• 114567-31-6 2-(2,4-Dimethyl-furan-3-ylmethyl)-5-methyl-benzene-1,3-diol 
• 114567-30-5 4-(2,4-Dimethyl-furan-3-ylmethyl)-5-methyl-benzene-1,3-diol 
• 79204-37-8 2,4-dimethyl-3-furylmethyl benzoate 

Relevant academic research and scientific papers

Reactions of ethyl diazoacetate with β-methylfurans

Reactions of β-methylfuran and 2,4-dimethylfuran with ethyl diazoacetate in the presence of [Rh2(OAc)4] catalyst, followed by iodine- induced isomerization, yielded furan ring-unravelled products. The results are compared with those of α-methylfurans.

Selective synthesis of 2,5-disubstituted furan-3-carboxylates and the isomeric 2,4-disubstituted furan-3-carboxylates

An unprecedented Ag2CO3 and DBU mediated cyclization of 3-substituted 2-(2-bromoallyl)-3-oxo-1-carboxylates leading to the formation of 2,5-disubstituted furan-3-carboxylates has been reported. In the absence of a silver salt, the is

Isotetronic acids from an oxidative cyclization

Oxidation of α,β-unsaturated methyl ketones with selenium dioxide leads to a cascade of reactions culminating in the formation of isotetronic acids.

Reaction of Corey ylide with α,β-Unsaturated Ketones: Tuning of Chemoselectivity toward Dihydrofuran Synthesis

A straightforward, efficient, and reliable approach to synthetically valuable 2,3-dihydrofurans via a reaction between Corey ylide and α,β-unsaturated ketones has been developed. The use of simple and widely spread starting materials as well as mild reaction conditions and scalability provide a broad scope of 2,3-dihydrofurans.

CuO/CNTs-catalyzed heterogeneous process: A convenient strategy to prepare furan derivatives from electron-deficient alkynes and α-hydroxy ketones

As heterogeneous catalysts and nanoparticle support materials, CNTs have attracted great interest in organic chemistry. This paper reports facile CuO/CNTs-catalyzed cyclization to form furan derivatives from electron-deficient alkynes and α-hydroxy ketones. It represents a facile synthetic route, and the eco-friendly catalyst can be easily separated by filtration and reused.

A New Platinum Complex Catalyzed Reaction Involving Nucleophilic Substitution at the Central Carbon Atom of the π-Allyl Ligand

The reaction of 2-chloro-allyl acetate with sodium ethyl acetoacetate in the presence of a platinum-(0) complex gave furan derivatives. The key feature of this new platinum-catalyzed reaction is the nucleophilic substitution at the central carbon atom of π-allyl complexes. The regioselectivity of the nucleophilic attacks (central or terminal) is dependent on the pKa of the nucleophile. In addition, a labeling experiment revealed that a rapid syn-anti isomerization of the (π-allyl) platinum complexes occurs.

Heterocyclization reaction of propargyl acetate with β-dicarbonyl compounds

The regiochemistry of the reaction of propargyl acetate with CH acids in the presence of mercury (II) acetate in dimethylsulfoxide has been investigated. Derivatives of furan or unsaturated diketones were isolated depending on the nature of the 1,3-dicarbonyl and the possibility of reduction of the organomercury intermediate. 1999 Kluwer Academic/Plenum Publishers.

Facile strategy to 3-acylfurans by silver(I)/celite-mediated cycloaddition of 1,3-dicarbonyl compounds to vinyl sulfides. First total synthesis of α-clausenan

An efficient synthesis of 3-acylfurans is achieved by silver((I)/Celite-mediated cycloaddition of dicarbonyl compounds, with vinyl sulfides.

Unsaturated Sulfoxides in Organic Synthesis: A New General Furan Synthesis

Furans have been efficiently synthesised by a three-step reaction sequence.Michael addition of keto esters to alkenyl sulfoxides followed by Pummerer rearrangement afforded the cyclic intermediates 11 in good yield.Treatment of the latter with 3-chloroperoxybenzoic acid led by oxidation and syn-elimination of the corresponding sulfoxide, to substituted furans.

A STRATEGY TO 3-ACYL-4-METHYL FURANS. SYNTHESIS OF (+/-)-EVODONE

Synthesis of Evodone 1 via the radical cyclisation of the bromoacetal 4 to methylene tetrahydrofuran 5 is described.