61485-25-4

Upstream product

• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 
• 105-56-6 ethyl 2-cyanoacetate 
• 74-88-4 methyl iodide 

Downstream Products

• 953806-09-2 5⁽³⁾-Amino-3⁽⁵⁾-(phenylamino)pyrazol-4-carbonsaeure-ethylester 
• 107427-98-5 ethyl-3,4-dihydro-6-methylthio-4-oxo-2,3-diphenylpyrimidine-5-carboxylate 
• 291509-16-5 4-amino-2-(2-carbethoxy-2-cyano)-N-phenyl-[10b]-hydro-2H-thiazino(5,4-c)coumarin 
• 1198400-37-1 C₁₈H₂₃N₅O₂S 
• 1269119-58-5 C₁₅H₁₆N₂O₃S 
• 1269119-62-1 C₁₅H₁₆N₂O₅S 
• 189108-85-8 ethyl 3-(aminomethyleneamino)-2-cyano-3-(phenylamino)acrylate 
• 761408-64-4 ethyl 4-chloro-6-(phenylamino)pyrimidine-5-carboxylate 
• 1138244-80-0 C₂₀H₁₇N₅OS₂ 
• 82685-14-1 5,5'-Diamino-3,3'-dianilino-1,1'-bipyrazol-4,4'-dicarbonsaeurediethylester 

Relevant academic research and scientific papers

One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives

A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1–29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Addit

Triflic acid-mediated N-heteroannulation of β-anilino-β-(methylthio)acrylonitriles: a facile synthesis of 4-amino-2-(methylthio)quinolines

Various functionalised 4-amino-2-(methylthio)quinolines are synthesised through triflic acid-mediated N-heteroannulation of α-functionalized-β-anilino-β-(methylthio)acrylonitriles for the first time. The N-heteroannulation process is highly chemoselective and has mild reaction conditions. However, this process fails in the absence of the β-methylthio group in the acrylonitriles. In addition, a new double N-heteroannulation process is demonstrated to synthesise indolo[3,2-c]quinolines from non-heterocyclic precursors. Natural product isocryptolepine is synthesised in four steps from an acyclic precursor.

Design and synthesis of potent N-phenylpyrimidine derivatives for the treatment of skin cancer

The development of novel synthetic compounds for the treatment of skin cancer is much needed, as there is a sudden rise in the incidence of skin cancer throughout the world and the available chemotherapy is facing problems of resistance. Hence, present re

FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

Heteroatom Rearrangements. S,N, O,N, and N,N Double Rearrangements. X-Ray Molecular Structure of 5-Cyano-6-methylthio-2,3-diphenyl-pyrimidin-4(3H)-one

New heteroatom rearrengements are reported; 'S,N, O,N, and N,N double rearrangements' take place when acrylonitriles, substituted at C-3 by two heteroatom groups (MeS or MeSe, and SH, OH, or NHPh), condense with aromatic carboxylic acids in the presence o

Radical Reactions of N-Heterocyclic Compounds. I. Synthesis and Structure of an N,N-Linked Bipyrazole

5(3)-Amino-3(5)-(phenylamino)-pyrazole-4-carboxylic acid ethyl ester (1), which is a very good antioxidant, reacts under mild reaction conditions with dibenzoyl peroxide or with tert.-butoxy radicals under formation of a bipyrazole 4.Evidence of the struc