61487-06-7

Usage

Uses

Used in Pharmaceutical Industry:
1 3-DIHYDRO-4-(2-HYDROXYPHENYL)-2H-1 5-& is used as a therapeutic agent for its potential to inhibit the growth of cancer cells. Its antioxidant and anti-inflammatory properties make it a candidate for the development of treatments targeting various types of cancer.
Used in Cardiovascular Health Applications:
In the field of cardiovascular health, 1 3-DIHYDRO-4-(2-HYDROXYPHENYL)-2H-1 5-& is utilized for its potential to promote heart health, possibly reducing the risk of cardiovascular diseases through its beneficial effects on the circulatory system.
Used in Neuroprotective Therapies:
1 3-DIHYDRO-4-(2-HYDROXYPHENYL)-2H-1 5-& is employed as a neuroprotective agent, with research suggesting its potential to protect and support the health of the central nervous system, making it a candidate for treatments related to neurological disorders and brain health.
Overall, the diverse applications of 1 3-DIHYDRO-4-(2-HYDROXYPHENYL)-2H-1 5-& in different industries highlight its potential as a versatile compound for therapeutic interventions. Ongoing research aims to further explore and harness its properties for the development of new treatments and therapies.

InChI:InChI=1/C15H12N2O2/c18-14-8-4-1-5-10(14)13-9-15(19)17-12-7-3-2-6-11(12)16-13/h1-8,18H,9H2,(H,17,19)

Upstream product

• 15938-69-9 3,3'-(2-oxo-2-phenylethane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one) 
• 95-54-5 1,2-diamino-benzene 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Relevant academic research and scientific papers

Design and microwave-assisted synthesis of dimers of 1,5-benzodiazepine-1,2,3-triazole hybrids bearing alkyl/aryl spacers and their biological assessment

Large series of novel N-bis-1,2,3-triazolo-linked-1,5-benzodiazepin-2-ones (BZD) have been synthesized under microwave irradiation through a Cu(I)-catalyzed double 1,3-dipolar alkyne-azide coupling reaction. This process is of considerable synthetic advantages in terms of time saving and remarkable yields. The chemical structures of the isolated compounds have been elucidated on the basis of extensive spectroscopic methods including 1D & 2D NMR, IR and HRMS. All the synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. In vitro antimicrobial environment, almost all of compounds have shown an interesting activity. Among the dimers of 1,5-benzodiazepine-1,2,3-triazole compounds tested, the results revealed that the potent antibacterial was recorded to compounds 3g,l for Gram-positive (within MIC = 31.25 and 125 μg/mL), and 3h,k for Gram-negative (within MIC = 31.25 and 125 μg/mL). Besides, the results demonstrate that compounds 3h,k have demonstrated the strongest potential against all the tested fungus (within MIC = 62.5 and 125 μg/mL). The antioxidant evaluation indicated that most compounds exhibited a moderate to good biological activity.

Highly diastereoselective synthesis of rigid 3-enamino-1, 5-benzodiazepines

A variety of new (3-Z)-3-((alkyl/aryl)aminomethylene)-4-(2-hydroxyphenyl)-1, 3-dihydro-2H-1, 5-benzodiazepin-2-ones were synthesized via addition of primary amines on the benzopyrano[4, 3-c]-1H-1, 5-benzodizepin-2-one. High yields with excellent diastereoselectivity were obtained. The structure of cis-?-enamino-1, 5-benzodiazepine derivatives was characterized by 1D and 2D NMR and confirmed by an X-Ray diffraction analysis. All prepared compounds were evaluated for their in vitro antibacterial activities and promising results were given.

1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials

Photoluminescent materials, that are now ubiquitous in our everyday life, have particularly attracted the attention of the scientific community these past few years due to potential important applications such as in bioimaging, sensing, or optoelectronics

Solution and solid-state fluorescence of 2-(2′-hydroxyphenyl)-1,5-benzodiazepin-2-one (HBD) borate complexes

A new family of fluorescent 1,5-benzodiazepin-2-one (HBD) borate complexes was prepared in good yields, and fully characterized by means of MS, NMR and IR spectroscopy, as well as X-ray crystal structure analysis for compound 13. Unlike their uncomplexed congeners, most of these cyclic boranils were emissive both in solution and the solid state, with maxima in the range of 426-596 nm. A systematic study of substituent effects revealed that the presence of a halogen atom specifically at position 8 of the fused-aromatic ring system led to an increase in fluorescence intensity in solution while electron rich substituents tended to extinguish the photoluminescence. Finally, a proof-of-concept study highlighted that the amide moiety of the benzodiazepinone framework could be functionalized with a chemical handle useful for subsequent specific modifications.

INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY

The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.

Aroyl[bis(4-hydroxycoumarin-3-yl)]methanes in reactions with 1,2-diaminobenzenes

The reaction of aroyl[bis(4-hydroxycoumarin-3-yl)]methanes with 1,2-phenylenediamines in PriOH is accompanied by the recyclization to 8-R-or 7-R-4-(2-hydroxyphenyl)-1,5-benzodiazepin-2-ones, whereas the reaction with o-phenylenediamine and its

Synthesis of some new biologically active coumarin derivatives

The reaction of 4-hydroxycoumarin in toluene with a variety of aromatic binucleophilic compounds has been studied. 3-(Dimethylaminomethylene)chromane-2, 4-dione was used as a key intermediate for the preparation of bis[N-(4-oxocoumarinylmethylene)]-1,4-di

New method of synthesis of 1,5-benzodiazepin-2-ones from 4-hydroxycoumarin

A new method of synthesis of 1,5-benzodiazepine-2-ones, from 4-hydroxycoumarin and substituted 1,2-phenylenediamines by heating in xylene or acetic acid-ethanol, is reported.