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Usage

Uses

Used in Sports Nutrition:
3-Hydroxy-3-methylbutanoic acid methyl ester is used as a nutritional supplement for athletes and bodybuilders to enhance muscle mass and strength. It supports muscle protein synthesis and reduces muscle protein breakdown, contributing to improved athletic performance and faster recovery.
Used in Health Management:
3-Hydroxy-3-methylbutanoic acid methyl ester is used as a potential therapeutic agent for managing health conditions associated with muscle breakdown, such as muscle wasting, osteoporosis, and cancer cachexia. Its impact on muscle protein synthesis and reduction of muscle protein breakdown may help alleviate symptoms and improve the quality of life for individuals suffering from these conditions.

Upstream product

• 6832-16-2 methyl diazoacetate 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 79-20-9 acetic acid methyl ester 
• 67-64-1 acetone 
• 2568-33-4 3-methyl-butane-1,3-diol 

Relevant academic research and scientific papers

Carbenes in a Rigid Matrix. Substituent Effects on the Temperature Dependence of α-Carbonylcarbene Reactions

The temperature dependence of methoxycarbonyl- (1a and b) and benzoyl-carbenes (2a and b) reactions in alcohols has been examined in order to elucidate the scope and limitation of low temperature photolysis as a tool for detecting triplet carbenes.The results reveal that the method cannot be applied to all carbenes but gives important information on the reactivity and/or multiplicity of ground-state carbenes.Low-temperature photolysis of PhCN2CO2Me in an ethanol matrix, for example, resulted in a dramatic increase in C-H insertion products, probably derived from the triplet (1a) via an abstraction-recombination mechanism, at the expense of the singlet product, i.e. the O-H insertion compound, which was shown to be the main product of photolysis at ambient temperature.In marked contrast, (1b) generated in a propan-2-ol matrix at -196 deg C did not result in a major increase in the C-H insertion product.Similar and more contrasting substituent effects on the temperature dependence were observed in the benzoylcarbene system (2).Thus, the Wolff rearrangement of (2a) was almost completely supressed in a rigid matrix at -196 deg C, whereas that of (2b) was not appreciably supressed even at -196 deg C.These differences were explained by considering the effects of the substituent on the ground-state multiplicity of carbene and/or on the relation of the activation energy differences of the singlet and triplet reactions with energy differences between two states.

Mechanism of the Photochemical Wolff Rearrangement. The Role of Conformation in the Photolysis of α-Diazo Carbonyl Compounds.

Investigation of photochemical processes of several α-diazo carbonyl compounds reveals that the Wolff rearrangement to form ketene takes place directly from the singlet excited state of the s-Z conformer whereas the excited state of the s-E conformer dissociates nitrogen to generate singlet carbonyl carbene, which either undergoes characteristic carbenic reactions, e.g., insertion and 1,2-hydrogen shift, or gives rise to ketene.The migratory aptitude as well as the relative efficiency of other competing reactions from singlet carbene is shown to be an important factor in dete rmining which reaction pathway is favored.Substantial amounts of singlet carbene can be formed even under sensitized conditions, presumably via intersystem crossing from initially formed triplet carbene.