61496-24-0

Usage

Uses

Used in Organic Synthesis:
(2-METHYL-2H-PYRAZOL-3-YL)-PHENYL-METHANONE is used as a building block for the synthesis of various biologically active molecules, contributing to the development of new compounds with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2-METHYL-2H-PYRAZOL-3-YL)-PHENYL-METHANONE is utilized in the development of new drugs, leveraging its unique structure to create molecules with enhanced biological activity and therapeutic potential.
Used in Antimicrobial Applications:
(2-METHYL-2H-PYRAZOL-3-YL)-PHENYL-METHANONE has been studied for its potential antimicrobial properties, making it a candidate for the development of new antibiotics or antimicrobial agents to combat resistant strains of bacteria.
Used in Anti-inflammatory Applications:
(2-METHYL-2H-PYRAZOL-3-YL)-PHENYL-METHANONE has also been investigated for its anti-inflammatory properties, suggesting its potential use in the development of anti-inflammatory drugs for the treatment of various inflammatory conditions.

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 
• 98-88-4 benzoyl chloride 
• 455-32-3 benzoyl fluoride 
• 92524-99-7 1-methyl-5-(trimethylsilyl)-1H-pyrazole 

Downstream Products

• 148408-72-4 (R)-(+)-1-Methyl-α-phenyl-1H-pyrazole-5-methanol 
• 148981-62-8 (R)-(+)-Cizolirtine 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity

HIF-1 is regarded as a promising target for the drugs used in cancer chemotherapy, and creating readily accessible templates for the development of synthetic drug candidates that could inhibit HIF-1 transcriptional activity is an important pursuit. In this study, indeno[2,1-c]pyrazolones were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4–5 steps from commercially available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound 3c showed a higher level compared with that of known inhibitor, YC-1. The compound 3c suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA.

METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to methyl-1H-pyrazole alkylamine compounds having this pharmacological activity, to process

Regioselective Halo- and Carbodesilylation of (Trimethylsilyl)-1-methylpyrazoles

The isomeric 3-, 4-, and 5-(trimethylsilyl)- as well as the 3,4-, 3,5-, and 4,5-bis(trimethylsilyl)-1-methylpyrazoles (2, 7, 3, 5, 9, and 10, respectively) are obtained by methylation of the corresponding (trimethylsilyl)-1H-pyrazoles or by silylation of Grignard or lithio derivatives of appropriate 1-methylpyrazoles with chlorotrimethylsilane. 5 and 10 are halodesilylated regioselectively by Br2 or ICl in the 4-position, yielding 13 and 15.With addditional bromine, these monobromo compounds suffer exclusively bromodesilylation to give 3,4- and 4,5-dibromo-1-methylpyrazole (14 and 16, respectively).These findings are in accord with the electrophilic substitution reactivity indices for 1-methylpyrazole (8) and with ipso-directing influence of the Me3Si group.The reaction of 5 with I2, unexpectedly, attacks preferentially at the 3-position.Regioselective carbodesilylation in the 5-position is observed in the fluoride-catalyzed reactions of 3, 9, and 10 with carbon electrophiles.The high regiospecificity of this reaction is rationalized in terms of carbanion stabilization at the individual pyrazole positions.