6150-03-4Relevant academic research and scientific papers
MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINONITRILE COMPOUND AND MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINO ACID
-
Paragraph 0014; 0028, (2017/12/27)
PROBLEM TO BE SOLVED: To provide a method for manufacturing an optically active aminonitrile compound with high purity suitable for manufacturing optically active amino acid and a method for manufacturing an optically active amino acid. SOLUTION: An optically active imine compound is obtained by condensing an optically active primary amine compound and a carbonyl compound in a solvent, a crystal of an optically active aminonitrile compound is deposited by adding hydrogen cyanide or a salt thereof to the imine compound in a solvent and asymmetric amplification for extremely enhancing diastereomer ratio thereof is conducted. The resulting aminonitrile compound with high optical purity is converted to optically active amino acid by known acid hydrolysis without deteriorating optical purity. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT
Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis
Crampton, Rosemary,Woodward, Simon,Fox, Martin
, p. 903 - 906 (2011/06/19)
Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.
