615285-08-0Relevant academic research and scientific papers
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product
Nicolaou,Chen, David Y.-K.,Li, Yiwei,Uesaka, Noriaki,Petrovic, Goran,Koftis, Theocharis V.,Bernal, Federico,Frederick, Michael O.,Govindasamy, Mugesh,Ling, Taotao,Pihko, Petri M.,Tang, Wenjun,Vyskocil, Stepan
, p. 2258 - 2267 (2006)
The key building blocks (6, 7, and 8) for the intended construction of the originally proposed structures of azaspiracid-1, a potent marine-derived neurotoxin, were coupled and the products elaborated to the targeted compounds (1a,b) and their C-20 epimer
Total synthesis of the proposed azaspiracid-1 structure, Part 1: Construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments
Nicolaou,Li, Yiwei,Uesaka, Noriaki,Koftis, Theocharis V.,Vyskocil, Stepan,Ling, Taotao,Govindasamy, Mugesh,Qian, Wenyuan,Bernal, Federico,Chen, David Y.-K.
, p. 3643 - 3648 (2007/10/03)
As a build-up to the synthesis of the proposed structure of azaspiracid, both enantiomers of fragments 2, 3, and 4 were synthesized stereoselectively. Piv=pivaloyl, PFP = pentafluorophenyl, Teoc = 2-(trimethylsilyl)ethoxycarbonyl, TES = triethylsilyl.
