61532-35-2

Basic information

• Product Name: 1-phenyl-1H-imidazo[4,5-c]pyridine
• Synonyms: 1-phenyl-1H-imidazo[4,5-c]pyridine
• CAS NO: 61532-35-2
• Molecular Formula: C₁₂H₉N₃
• Molecular Weight: 195.21996
• Mol File: 61532-35-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-phenyl-1H-imidazo[4,5-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1H-imidazo[4,5-c]pyridine(61532-35-2)
• EPA Substance Registry System: 1-phenyl-1H-imidazo[4,5-c]pyridine(61532-35-2)

Safety Data

• Hazardous Substances Data: 61532-35-2(Hazardous Substances Data)

Usage

Molecular structure

A phenyl group attached to an imidazo[4,5-c]pyridine ring system.

Type of compound

Heterocyclic aromatic compound.

Potential applications

Medicinal chemistry and drug development.

Known for

Ability to interact with biological targets, such as receptors or enzymes.

Value

Valuable scaffold for the design of novel pharmaceutical agents.

Possible pharmacological properties

Anti-cancer, anti-inflammatory, or antimicrobial activities.

Subject of interest

Further research and investigation in the field of chemical and biological sciences.

Upstream product

• 272-97-9 Imidazo<4,5-c>pyridin 
• 64-18-6 formic acid 
• 35826-31-4 3-amino-4-(phenylamino)pyridine 
• 35750-90-4 4-(N-phenylamino)-3-nitropyridine 
• 3473-63-0 formamidine acetic acid 
• 62-53-3 aniline 
• 13091-23-1 4-chloro-3-nitropyridine 

Downstream Products

• 1078168-14-5 C₁₂H₉N₃O 
• 87673-89-0 1-phenyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 
• 61531-50-8 1-Phenyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-thione 

Relevant articles and documents

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

The synthesis and SAR of a series of 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridine P2X7 antagonists are described. Addressing P2X7 affinity and liver microsomal stability issues encountered with this template afforded methyl substituted 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridines ultimately leading to the identification of 1 (JNJ 54166060). 1 is a potent P2X7 antagonist with an ED50 = 2.3 mg/kg in rats, high oral bioavailability and low-moderate clearance in preclinical species, acceptable safety margins in rats, and a predicted human dose of 120 mg of QD. Additionally, 1 possesses a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism.

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.