6154-89-8

Basic information

• Product Name: 2,4-dichloro-N-[5-(4-methylphenyl)-1H-pyrazol-3-yl]benzamide
• CAS NO: 6154-89-8
• Molecular Formula: C₁₇H₁₃Cl₂N₃O
• Molecular Weight: 346.2106
• Mol File: 6154-89-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 502.4°C at 760 mmHg
• Flash Point: 257.6°C
• Density: 1.411g/cm³
• Vapor Pressure: 3.19E-10mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: 2,4-dichloro-N-[5-(4-methylphenyl)-1H-pyrazol-3-yl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-N-[5-(4-methylphenyl)-1H-pyrazol-3-yl]benzamide(6154-89-8)
• EPA Substance Registry System: 2,4-dichloro-N-[5-(4-methylphenyl)-1H-pyrazol-3-yl]benzamide(6154-89-8)

Safety Data

• Hazardous Substances Data: 6154-89-8(Hazardous Substances Data)

Upstream product

• 499100-03-7 3,28-dihydroxyolean-12-ene 
• 1721-58-0 methyl 3-oxooleanolate 
• 1724-17-0 oleanolic acid methyl ester 
• 18100-49-7 3-Keto-methyl-oleanolat-ketal 
• 17990-42-0 Oleanonsaeure 
• 508-02-1 Oleanolic acid 
• 545-48-2 erythrodiol 
• 33608-08-1 3-oxoolean-12-en-28-al 

Relevant articles and documents

Chemoselective reduction of aldehydes: Via a combination of NaBH4 and acetylacetone

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient chemoselective reduction of aldehydes in the presence of ketones. This method offers a useful synthetic protocol for distinguishing carbonyl reaction sites, and its synthetic utility is reflected by its moisture tolerance and high efficiency in a variety of complex settings.

COMPOSITIONS COMPRISING TRITERPENOIDS AND USES THEREOF FOR TREATING OPTIC NEUROPATHY

The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating optic neuropathy conditions.

COMPOSITIONS COMPRISING TRITERPENOIDS

The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating for use in treating a condition selected from Alzheimer's disease (AD), Parkinson's Diseases (PD) and vascular dementia (VD).

Synthesis and biological evaluation of oleanolic acid derivatives as antitumor agents

Derivatives of oleanolic acid were synthesized and evaluated in vitro for their growth inhibition against human hepatocellular carcinoma cell line (HepG2) and colon cancer cell line (Col-02). Several derivatives exhibited moderate-to-good inhibitory activity, with 3 displaying the most promising inhibition [GI50=1.75μM (HepG2), 0.71μM (Col-02)]. Structure-activity relationship analyses of these derivatives demonstrated that a 1-en-2-cyano-3-oxo in ring A and a nitro at C-17 were important in retention of the inhibition against HepG2 and Col-02 cells.

Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in the process of insulin signaling and a promising drug target for diabetes and obesity. Derivatives of oleanolic acid were synthesized and evaluated as PTP1B inhibitors. Several derivatives exhibited moderate to good inhibitory activities against PTP1B, with 25f displaying the most promising inhibition (IC 50 = 3.12 μM). Structure-activity relationship analyses of these derivatives demonstrated that the integrity of the A ring and 12-ene moieties was important in the retention of PTP1B enzyme inhibitory activities. In addition, hydrophilic and acidic groups as well as the distance between the oleanene and acid moieties were associated with PTP1B inhibitory activities. Possible binding modes of 25f were explored by molecular docking simulations.