615569-07-8Relevant articles and documents
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases
Miles, Timothy J.,Barfoot, Christopher,Brooks, Gerald,Brown, Pamela,Chen, Dongzhao,Dabbs, Steven,Davies, David T.,Downie, David L.,Eyrisch, Susanne,Giordano, Ilaria,Gwynn, Michael N.,Hennessy, Alan,Hoover, Jennifer,Huang, Jianzhong,Jones, Graham,Markwell, Roger,Rittenhouse, Stephen,Xiang, Hong,Pearson, Neil
, p. 7483 - 7488 (2011)
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoisomer