615581-25-4

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 872450-69-6 methyl 2-(4-hydroxybutyl)benzoate 
• 872450-68-5 methyl 2-(4-hydroxybut-1-yn-1-yl)benzoate 
• 667909-38-8 2-((E)-3-[1,3]Dioxolan-2-yl-propenyl)-benzoic acid methyl ester 
• 86608-70-0 2-(1,3-dioxolan-2-yl)ethyl(triphenyl)phosphonium bromide 
• 615581-24-3 methyl 2-[3-(1,3-dioxolan-2-yl)propyl]benzoate 
• 134-20-3 2-carbomethoxyaniline 
• 1332285-11-6 2-(4,4-dimethoxybutyl)benzoic acid methyl ester 

Downstream Products

• 615581-26-5 methyl 2-(4-hydroxypentyl)benzoate 
• 615582-11-1 (1RS,5RS,10RS)-10-hydroxymethyl-1-methylspiro[4.5]dec-7-en-1-ol 
• 615582-10-0 (1RS,5RS,6RS)-6-hydroxymethyl-1-methylspiro[4.5]dec-7-en-1-ol 
• 256657-90-6 methyl 2-(4-oxopentyl)benzoate 

Relevant academic research and scientific papers

Stable Analogues of OSB-AMP: Potent Inhibitors of MenE, the o-Succinylbenzoate-CoA Synthetase from Bacterial Menaquinone Biosynthesis

MenE, the o-succinylbenzoate (OSB)-CoA synthetase from bacterial menaquinone biosynthesis, is a promising new antibacterial target. Sulfonyladenosine analogues of the cognate reaction intermediate, OSB-AMP, have been developed as inhibitors of the MenE en

PREPARATION OF 3,3-DIALKXOY-1-METHYLENEPROPYL ARENES

The invention discloses a method for the preparation of 3,3-dialkxoy-1-methylenepropyl arenes from crotonaldehyde and aryldiazonium salts, and intermediates for the preparation of perfumes.

PREPARATION OF 4,4-DIALKOXY-1-BUTEN-1-YLARENES

The invention discloses a method for the preparation of 4,4-dialkoxy-1-buten-1-ylarenes from crotonaldehyde and aryldiazonium salts, n-buten-1-als and n-butan-1-als derived thereof, their use as fragrances, use of this method in and intermediates for the

Direct C-4 arylation of crotonaldehyde with arenediazonium tetrafluoroborates

Arenediazonium tetrafluoroborates react with crotonaldehyde (2-butenal) in methanol in the presence of catalytic amounts of Pd(OAc)2 to yield mainly 4,4-dimethoxy-1-butenylarenes. In most of the examples studied, small amounts of an isomeric byproduct were formed, presumably 3,3-dimethoxy-1- methylenepropylarenes. Because crotonaldehyde and arenediazonium salts are cheap and readily available, this reaction is a convenient access to protected 4-arylbutenals.

Samarium(II)-promoted radical spirocyclization onto an aromatic ring

Samarium(II)-mediated spirocyclization onto an aromatic ring was achieved by the reaction of methyl 4-(4-oxoalkyl)benzoates with SmI2 in the presence of i-PrOH and HMPA, yielding methyl 1-alkyl-1-hydroxyspiro[4.5]dec-6-ene-8-carboxylates in moderate to high yields. Utilizing this chemistry, spiro[3.5] and -[5.5] systems, and sterically congested spiro[4.5] systems, were easily synthesized. For the successful conversion, appropriate activation of the aromatic ring has proven to be extremely important: while an ester or amide functionality on the aromatic ring can promote the spirocyclization, a sulfonamide substituent causes ortho cyclization.