6157-98-8

Usage

Uses

Used in Dye Production:
2,3,4,5-tetrafluoro-6-nitrobenzenaMine is used as a key intermediate in the production of dyes, where its specific properties contribute to the color and stability of the final product.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3,4,5-tetrafluoro-6-nitrobenzenaMine is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemicals:
2,3,4,5-tetrafluoro-6-nitrobenzenaMine is also utilized in the production of agrochemicals, where it serves as a precursor for the synthesis of compounds with pesticidal or herbicidal activity.
Used in Organic Synthesis:
As a versatile building block, 2,3,4,5-tetrafluoro-6-nitrobenzenaMine is used in the synthesis of a wide range of organic compounds, enabling the creation of materials with tailored properties for various applications.
Safety Precautions:
It is important to handle 2,3,4,5-tetrafluoro-6-nitrobenzenaMine with care, as it can be toxic if ingested or inhaled, and may cause skin and eye irritation. Proper safety measures should be taken during its production, use, and disposal to minimize potential health risks.

Upstream product

• 16582-88-0 N-(2,3,4,5-tetrafluorophenyl)acetamide 
• 880-78-4 pentafluoronitrobenzen 
• 16582-89-1 2.3.4.5-Tetrafluor-6-nitro-acetanilid 

Downstream Products

• 16582-87-9 1,2,3,4-tetrafluoro-5,6-dinitrobenzene 
• 2993-07-9 3,4,5,6-tetrafluoro-benzene-1,2-diamine 
• 52751-37-8 2-Azo-3-nitrotrifluor-3,5-cyclohexadien-1-on 
• 3228-15-7 2-NO₂-C₆F₄N(CH₃)2 
• 1423543-40-1 2,3,4,5-Tetrafluoro-6-nitro-1-difluoraniline 
• 26888-63-1 5,6,7,8-tetrafluoro-2,3-diphenylquinoxaline 
• 39063-17-7 N,N-(perfluoro-1,2-phenylene)bis(2,2,2-trifluoroethanamide) 
• 2355-43-3 4,5,6,7-Tetrafluor-2-trifluormethyl-benzimidazol 
• 4920-46-1 4,5,6,7-tetrafluorobenzimidazole 
• 26888-72-2 4,5,6,7-tetrafluorobenzotriazole 
• 14851-16-2 2-Amino-6-methylamino-3,4,5-trifluornitrobenzol 
• 14851-18-4 2-Dimethylamino-6-amino-3,4,5-trifluornitrobenzol 
• 14851-20-8 2-Amino-6-methoxy-3,4,5-trifluor-nitrobenzol 
• 2338-46-7 2,4,5-Trifluor-6-nitro-3-aethoxy-anilin 

Relevant academic research and scientific papers

Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity

Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for Kv7.2/Kv7.3 over related potassium channels, i.e., Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5. RL-36 and RL-12 maintain an agonist EC2x of ca. 1 μM on Kv7.2/Kv7.3 in a high-throughput assay on an automated electrophysiology platform in HEK293 cells but lack activity on Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC2x 0.11 ± 0.02 μM, and still shows an SI = 2.5. We also identified analogues with significant selectivity for Kv7.4/Kv7.5 over Kv7.2/Kv7.3. The extensive use of fluorine in iterative core structure modifications highlights the versatility of these substituents, including F, CF3, and SF5, to span orders of magnitude of potency and selectivity in medicinal chemistry lead optimizations.

SELECTIVE POTASSIUM CHANNEL AGONISTS

Selective potassium channel agonists and methods of use thereof are disclosed. A compound, or a pharmaceutically acceptable salt thereof, having a formula (I) wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted C1-C6 alkyl or optionally- substituted cyclopropyl; R3 and R4 are each independently H or optionally- substituted alkyl; R5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R6 and R7 are each independently H, optionally- substituted alkyl, or R6 and R7 together form a carbocycle; R8 is substituted phenyl or optionally-substituted pyridinyl, provided that if R8 is substituted phenyl, then R2 is optionally-substituted cyclopropyl; and R9, R10 and R11 are each independently H, halo, or optionally- substituted alkyl.

Continuous flow synthesis of difluoroamine systems by direct fluorination

Continuous flow methodology for the synthesis of perfluoroaryl difluoroamine derivatives by reaction of fluorine gas with an appropriate perfluoroaniline substrate is described, further demonstrating the efficient use of flow regimes for reactions involvi

2-(4,5,6,7-Tetrafluorobenzimidazol-2-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1- H-imidazole-3-oxide-1-oxyl, a hydrogen-bonded organic quasi-1D ferromagnet

The title radical (F4BImNN) is a stable nitronylnitroxide that forms hydrogen-bonded NH?ON chains in the solid state. The chains assemble the F4BImNN molecules to form stacked contacts between the radical groups, in a geometry that is expected to exhibit

CHARGE-TRANSPORT MATERIALS, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF

Briefly described, embodiments of this disclosure include charge-transport materials, methods of forming charge-transport materials, and methods of using the charge-transport materials.

Cancer treatment

This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing a tetra-substituted benzimidazole carbamate. The tetra-substituted benzimidazole carbamate is selected f

Polyhalogenonitrobenzenes and derived compounds: Part 5. Improved preparations of 1,2,3,4-tetrafluoro-5,6-dinitrobenzene and 3,4,5,6-tetrafluoro-1,2-phenylenediamine, and the use of the latter for the synthesis of tetrafluorobenzheterocycles

The preparation of 2,3,4,5-tetrafluoro-6-nitroaniline (3) by amination of pentafluoronitrobenzene has been speeded up, scaled up and the yield increased by controlling the reaction by TLC monitoring and using 'dry column' chromatography. Compound (3) was readily converted to 1,2,3,4-tetrafluoro-5,6-dinitrobenzene (2) by peroxytrifluoroacetic acid and to 3,4,5,6-tetrafluoro-1,2-phenylenediamine (1) by SnCl2/HCl, Compound (1) was shown to be a versatile intermediate for the synthesis of tetrafluoro-benzimidazoles, -triazoles and -quinoxalines. The fungicidal activity of the latter are reported here.

Glycine receptor antagonists and the use thereof

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.

REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. X. AMINATION OF POLYFLUORINATED AROMATIC COMPOUNDS CONTAINING ELECTRON-WITHDRAWING SUBSTITUENTS

It was shown for the case of 2,4-difluoro-, 2,4,6-trifluoro-, and pentafluoronitrobenzenes that both liquid ammonia and sodium amide in liquid ammonia are effective reagents for aminodefluorination with respect to the fluorine derivatives of nitrobenzene.The observed tendency for the ortho-orientation with respect to the nitro group to change to para-orientation with increase in the number of fluorine atoms is more clearly defined for sodium amide than for liquid ammonia as nucleophile on account, clearly, of the stabilization of the transition state of ortho-substitution in the latter case by an intramolcular hydrogen bond.