6157-98-8

Basic information

• Product Name: 2,3,4,5-tetrafluoro-6-nitrobenzenaMine
• Synonyms: 2,3,4,5-tetrafluoro-6-nitrobenzenaMine;2-Amino-3,4,5,6-tetrafluoronitrobenzene;2-Nitro-3,4,5,6-tetrafluoroaniline 97%;2,3,4,5-Tetrafluoro-6-nitroaniline;2-Nitro-3,4,5,6-tetrafluoroaniline97%
• CAS NO: 6157-98-8
• Molecular Formula: C₆H₂F₄N₂O₂
• Molecular Weight: 210.0858928
• Mol File: 6157-98-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3,4,5-tetrafluoro-6-nitrobenzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-tetrafluoro-6-nitrobenzenaMine(6157-98-8)
• EPA Substance Registry System: 2,3,4,5-tetrafluoro-6-nitrobenzenaMine(6157-98-8)

Safety Data

• Hazardous Substances Data: 6157-98-8(Hazardous Substances Data)

Usage

General Description

2,3,4,5-tetrafluoro-6-nitrobenzenaMine, also known as 2,3,4,5-tetrafluoro-6-nitroaniline, is a chemical compound with the molecular formula C6H3F4N2O2. It is a yellow to brown solid with a melting point of 133-135°C. 2,3,4,5-tetrafluoro-6-nitrobenzenaMine is used in the production of dyes, pharmaceuticals, and agrochemicals. It is also a versatile building block for the synthesis of various organic compounds. The presence of multiple fluorine and nitro groups makes 2,3,4,5-tetrafluoro-6-nitrobenzenaMine a valuable component in the development of novel materials and functional molecules with specific properties. However, it is important to handle this chemical with caution, as it can be toxic if ingested or inhaled, and may cause skin and eye irritation.

Upstream product

• 16582-88-0 N-(2,3,4,5-tetrafluorophenyl)acetamide 
• 880-78-4 pentafluoronitrobenzen 
• 16582-89-1 2.3.4.5-Tetrafluor-6-nitro-acetanilid 

Downstream Products

• 3228-15-7 2-NO₂-C₆F₄N(CH₃)2 
• 52751-37-8 2-Azo-3-nitrotrifluor-3,5-cyclohexadien-1-on 
• 16582-87-9 1,2,3,4-tetrafluoro-5,6-dinitrobenzene 
• 2993-07-9 3,4,5,6-tetrafluoro-benzene-1,2-diamine 
• 26888-63-1 5,6,7,8-tetrafluoro-2,3-diphenylquinoxaline 
• 39063-17-7 N,N-(perfluoro-1,2-phenylene)bis(2,2,2-trifluoroethanamide) 
• 2355-43-3 4,5,6,7-Tetrafluor-2-trifluormethyl-benzimidazol 
• 4920-46-1 4,5,6,7-tetrafluorobenzimidazole 
• 26888-72-2 4,5,6,7-tetrafluorobenzotriazole 
• 14851-16-2 2-Amino-6-methylamino-3,4,5-trifluornitrobenzol 
• 14851-18-4 2-Dimethylamino-6-amino-3,4,5-trifluornitrobenzol 
• 14851-20-8 2-Amino-6-methoxy-3,4,5-trifluor-nitrobenzol 
• 2338-46-7 2,4,5-Trifluor-6-nitro-3-aethoxy-anilin 
• 2106-01-6 4,5,6-trifluoro-2-nitro-1,3-phenylenediamine 

Relevant articles and documents

Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity

Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for Kv7.2/Kv7.3 over related potassium channels, i.e., Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5. RL-36 and RL-12 maintain an agonist EC2x of ca. 1 μM on Kv7.2/Kv7.3 in a high-throughput assay on an automated electrophysiology platform in HEK293 cells but lack activity on Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC2x 0.11 ± 0.02 μM, and still shows an SI = 2.5. We also identified analogues with significant selectivity for Kv7.4/Kv7.5 over Kv7.2/Kv7.3. The extensive use of fluorine in iterative core structure modifications highlights the versatility of these substituents, including F, CF3, and SF5, to span orders of magnitude of potency and selectivity in medicinal chemistry lead optimizations.

Continuous flow synthesis of difluoroamine systems by direct fluorination

Continuous flow methodology for the synthesis of perfluoroaryl difluoroamine derivatives by reaction of fluorine gas with an appropriate perfluoroaniline substrate is described, further demonstrating the efficient use of flow regimes for reactions involvi

CHARGE-TRANSPORT MATERIALS, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF

Briefly described, embodiments of this disclosure include charge-transport materials, methods of forming charge-transport materials, and methods of using the charge-transport materials.