61591-82-0Relevant academic research and scientific papers
Radical α,β-Dehydrogenation of Saturated Amides via α-Oxidation with TEMPO under Transition Metal-Free Conditions
Wang, Mei-Mei,Sui, Guo-Hui,Cui, Xian-Chao,Wang, Hui,Qu, Jian-Ping,Kang, Yan-Biao
, p. 8267 - 8274 (2019/06/27)
A transition metal-free radical process for the selective α,β-dehydrogenation of saturated amides under mild conditions is developed. Utilizing radical activation strategy, the challenging issue associated with the low α-acidity of amides is resolved. For the first time, α,β-unsaturated Weinreb amides and acrylamides could be efficiently prepared directly from corresponding saturated amides. Mechanistic studies confirm the radical nature of this transformation. Two gram scale α,β-dehydrogenation have also been performed to demonstrate the utility of this method.
Synthesis of optically active N-aryl amino acid derivatives through the asymmetric petasis reaction catalyzed by a novel hydroxy-thiourea catalyst
Inokuma, Tsubasa,Suzuki, Yusuke,Sakaeda, Toshiyuki,Takemoto, Yoshiji
supporting information; experimental part, p. 2902 - 2906 (2012/06/30)
Thiourea makes peptides: Asymmetric Petasis reactions with vinylboronates and α-iminoamides are effectively catalyzed by the novel hydroxy-thiourea catalyst 1 (up to 86% yield, 93% ee; see scheme). This reaction can be applied not only to the synthesis of
