61593-17-7

Basic information

• Product Name: 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE
• Synonyms: 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE;1-(2-chloro-phenyl)-2,2-dimethyl-propan-1-one
• CAS NO: 61593-17-7
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.67
• Mol File: 61593-17-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 241.9°C at 760 mmHg
• Flash Point: 137.8°C
• Appearance: /
• Density: 1.077g/cm³
• Vapor Pressure: 0.0351mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE(61593-17-7)
• EPA Substance Registry System: 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE(61593-17-7)

Safety Data

• Hazardous Substances Data: 61593-17-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13ClO/c1-11(2,3)10(13)8-6-4-5-7-9(8)12/h4-7H,1-3H3

Upstream product

• 694-80-4 2-bromo-1-chlorobenzene 
• 3282-30-2 pivaloyl chloride 
• 2259-30-5 tert-butylmagnesium bromide 
• 609-65-4 o-chlorobenzoyl chloride 
• 108-90-7 chlorobenzene 
• 873-32-5 2-Chlorobenzonitrile 
• 677-22-5 tert-butylmagnesium chloride 
• 938-16-9 2,2-dimethylpropiophenone 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 74-88-4 methyl iodide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 61593-06-4 1-(2-Chlorphenyl)-1-phenyl-2,2-dimethylpropanol-1 
• 10489-28-8 2,2-dimethyl-indan-1-one 
• 61593-16-6 1-Chloro-2-(2,2-dimethyl-1-phenyl-propyl)-benzene 

Relevant articles and documents

Synergistic interplay of a non-heme iron catalyst and amino acid coligands in H2O2 activation for asymmetric epoxidation of α-alkyl-substituted styrenes

Highly enantioselective epoxidation of α-substituted styrenes with aqueous H2O2 is described by using a chiral iron complex as the catalyst and N-protected amino acids (AAs) as coligands. The amino acids synergistically cooperate with the iron center in promoting an efficient activation of H2O2 to catalyze epoxidation of this challenging class of substrates with good yields and stereoselectivities (up to 97% ee) in short reaction times.

Ultrasound assisted Friedel-Crafts acylation of aromatics using ferric sulphate as catalyst

The use of ultrasound in the acylation reactions of various aromatics and polyaromatics with different acyl chlorides, in the presence of catalytic amount of ferric sulphate at room temperature, gives good yields of the respective ketones with a short reaction time. A facile and simple synthesis of various aromatic ketones using Friedel-Crafts acylation has been established from the corresponding acid chlorides and aromatic or polyaromatic compounds, respectively under mild reaction conditions with shorter reaction times (30-45 min) and in reasonable yields. This method offers the advantage of low cost and ease of purification of the products because of the small amount of ferric sulphate used in these reactions.

Insertion of arynes into carbon-halogen σ-bonds: Regioselective acylation of aromatic rings

Arynes were found to insert into carbon-halogen σ-bonds of various acid halides, enabling acyl and halogen moieties to be introduced simultaneously into adjacent positions of aromatic rings. The Royal Society of Chemistry.