7097-89-4

Usage

Uses

Used in Organic Synthesis:
(2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE is used as a reagent in organic synthesis for the synthesis of various compounds. Its isothiocyanato group allows for the formation of diverse products, making it a valuable component in the creation of new chemical entities.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE serves as a building block in the production of various drugs. Its reactivity and structural properties contribute to the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, (2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE is utilized as a key component in the synthesis of crop protection agents and other agricultural products, enhancing crop yields and protection against pests.
Used in Dye Synthesis:
(2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE is also used as a reagent in the synthesis of dyes, contributing to the development of new colorants for various industries, including textiles, plastics, and printing.
Used in Biochemical and Molecular Biology Research:
In the realm of scientific research, (2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE plays a role in biochemical and molecular biology studies. Its unique chemical properties make it a useful tool for investigating biological processes and interactions at the molecular level.
Overall, (2-ISOTHIOCYANATO-ETHYL)-DIMETHYL-AMINE has a wide range of applications across the chemical industry and scientific research, making it an important compound for the development of new products and advancements in various fields.

InChI:InChI=1/C5H10N2S/c1-7(2)4-3-6-5-8/h3-4H2,1-2H3/p+1

Upstream product

• 75-15-0 carbon disulfide 
• 108-00-9 N,N-dimethylethylenediamine 
• 18997-69-8 2-(N,N-dimethylamino)ethylamino dithiocarboxylic acid 
• 463-71-8 thiophosgene 

Downstream Products

• 67749-33-1 N-[3-(2-dimethylamino-ethyl)-6,6-dimethyl-4-oxo-2-thioxo-[1,3]thiazinan-5-yl]-4-methanesulfonylamino-benzamide 
• 61607-68-9 1-[2-(dimethylamino)ethyl]-1,2-dihydro-5H-tetrazole-5-thione 
• 1440676-73-2 C₂₄H₃₄N₈S 
• 112563-06-1 2-(2-Methoxy-phenyl)-thiazolidine-3-carbothioic acid (2-dimethylamino-ethyl)-amide; hydrochloride 

Relevant academic research and scientific papers

Synthesis method of 1-(2-dimethylaminoethyl)-5-mercaptotetrazole

The invention belongs to the technical field of medicines, and particularly relates to a synthesis method of 1-(2-dimethylaminoethyl)-5-mercaptotetrazole. The method comprises the following steps: reacting N, N-dimethylethylenediamine with thiophosgene to obtain isothiocyanate, reacting isothiocyanate with azidotrimethylsilane to obtain 1-(2-dimethylaminoethyl)-5-mercaptotetrazole hydrochloride, dissolving 1-(2-dimethylaminoethyl)-5-mercaptotetrazole hydrochloride in water, and carrying out decolorizing and crystallizing to obtain 1-(2-dimethylaminoethyl)-5-mercaptotetrazole. According to themethod, the isothiocyanate is synthesized from the N, N-dimethylethylenediamine and the thiophosgene through a one-step method, so that the synthesis process is simplified and the yield is greatly increased; non-toxic azidotrimethylsilane is used for replacing virulent sodium azide in the cyclization process, so that the safety of the process is improved, and the method is more suitable for industrial amplification.

Catalyst-Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides

The biomimetic synthesis of aromatic polyketides from macrocyclic substrates by means of catalyst-controlled transannular cyclization cascades is described. The macrocyclic substrates, which feature increased stability and fewer conformational states, were thereby transformed into several distinct polyketide scaffolds. The catalyst-controlled transannular cyclizations selectively led to aromatic polyketides with a defined folding and oxygenation pattern, thus emulating β-keto-processing steps of polyketide biosynthesis.

Method for preparing isothiocyanate from ethyl chloroformate

The invention relates to a method for preparing isothiocyanate from ethyl chloroformate. The method comprises the following steps: taking a compound as shown in specification as a starting material, reacting with carbon disulfide to prepare inner salt, and then reacting the inner salt with ethyl chloroformate in an organic solvent at the temperature of 0-40 DEG C to prepare thio-mixed anhydride, wherein in the compound as shown in specification, n is 1, 2, 3, 4 or 5; and adding the mixed anhydride in an inorganic aqueous alkali, and hydrolyzing at the temperature of minus 5-30 DEG C to preparethe corresponding isothiocyanate. According to the preparation method, the mixed anhydride is synthesized at first, and then is hydrolyzed with inorganic alkali, application of organic alkali is avoided effectively, side reaction of the isothiocyanate and alcohol is relieved, and the reaction yield of the isothiocyanate and the purity of the product are improved.

Method for simultaneously synthesizing N,N-dimethyl ethylenediamine isothiocyanate and thioacetic acid

The invention relates to a method for simultaneously synthesizing N,N-dimethyl ethylenediamine isothiocyanate and thioacetic acid, and belongs to the field of preparation of medical intermediates. Themethod comprises the following steps: taking N,N-dimethyl ethylenediamine as a starting material; reacting the N,N-dimethyl ethylenediamine with carbon disulfide to prepare thio-inner salt; then reacting the thio-inner salt with acetylchloride to prepare thio-mixed anhydride; and hydrolyzing in an inorganic aqueous alkali at one step to prepare thioacetic acid and N,N-dimethyl ethylenediamine isothiocyanate. By the method, two different valuable products can be obtained simultaneously, operation steps are simplified, and emission of organic by-products is reduced.

Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques

One of the pathological hallmarks of Alzheimer's disease is the presence of amyloid-β plaques in the brain and the major constituent of these plaques is aggregated amyloid-β peptide. New thiosemicarbazone-pyridylhydrazine based ligands that incorporate functional groups designed to bind amyloid-β plaques have been synthesized. The new ligands form stable four coordinate complexes with a positron-emitting radioactive isotope of copper, 64Cu. Two of the new CuII complexes include a functionalized styrylpyridine group and these complexes bind to amyloid-β plaques in samples of post-mortem human brain tissue. Strategies to increase brain uptake by functional group manipulation have led to a 64Cu complex that effectively crosses the blood-brain barrier in wild-type mice. The new complexes described in this manuscript provide insight into strategies to deliver metal complexes to amyloid-β plaques.

NOVEL QUINOXALINE DERIVATIVES

This invention relates to a novel compound represented by the following Chemical Formula 1, a process for preparing it, and its pharmaceutically approved salt comprising it as an active ingredient. The compound of this invention is GLP 1 receptor regulating low molecular weight compound useful for treatment of metabolic diseases such as diabetes and obesity by regulating the function of glucagon like peptide 1 receptor (GLP 1 receptor) for the disease or disorder carried by GLP 1 since it has the effects on a drop of blood sugar and an improvement of insulin resistance

Synthesis of new alkylaminoalkyl thiosemicarbazones of 3-acetylindole and their effect on DNA synthesis and cell proliferation

The preparation of a number of thiobemicarbazones of 3-acetylindole is described. These compounds were evaluated in vitro for their effect on proliferation and cell-division delays in cultured human peripheral blood lymphocytes, and their effect on DNA synthesit in T-cell leukemia Molt-4 cells.

SULPHOXIDES

The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.