616238-78-9Relevant academic research and scientific papers
ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF
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Page/Page column 62, (2020/03/05)
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
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Paragraph 0461, (2020/03/01)
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
Discovery and optimization of p38 inhibitors via computer-assisted drug design
Goldberg, Daniel R.,Hao, Ming-Hong,Qian, Kevin C.,Swinamer, Alan D.,Gao, Donghong A.,Xiong, Zhaoming,Sarko, Chris,Berry, Angela,Lord, John,Magolda, Ronald L.,Fadra, Tazmeen,Kroe, Rachel R.,Kukulka, Alison,Madwed, Jeffrey B.,Martin, Leslie,Pargellis, Christopher,Skow, Donna,Song, Jinhua J.,Tan, Zhulin,Torcellini, Carol A.,Zimmitti, Clare S.,Yee, Nathan K.,Moss, Neil
, p. 4016 - 4026 (2008/02/12)
Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.
Compounds useful in treating cytokine mediated diseases
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Page 27, 35, 36, (2008/06/13)
Disclosed are amide compounds of formula(I): wherein Ar1, Q, Y and R3-R6 of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating d
