61636-31-5Relevant academic research and scientific papers
AlMe3-promoted formation of amides from acids and amines
Li, Jianqing,Subramaniam, Krishnananthan,Smith, Daniel,Qiao, Jennifer X.,Li, Jie Jack,Qian-Cutrone, Jingfang,Kadow, John F.,Vite, Gregory D.,Chen, Bang-Chi
supporting information; experimental part, p. 214 - 217 (2012/02/16)
In the presence of AlMe3, amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected se
Conformation and Stereodynamics of N,N-Dialkylbenzamides; a 1H and 13C Nuclear Magnetic Resonance Investigation of para-Substituted 4-Benzoyl-cis-2,6-dimethylmorpholines
Jennings, W. Brian,Saket, Barahman Movassagh
, p. 1005 - 1010 (2007/10/02)
A high-field 13C n.m.r. study of the title compounds below -80 deg C has enabled measurement of the barriers to rotation around the aryl-C(O) bond.These barriers (ΔG(excit.) 7.7-9.5 kcal mol-1), and those for rotation around the C(O)-N bond (ΔG(excit.) 13.6-15.6 kcal mol-1) determined by 1H n.m.r. at higher temperatures, correlate well with Hammett ?+ substituent parameters.The ground-state conformation has the phenyl ring twisted out of the amide plane.Some 1H and 13C chemical shift correlations are also reported.
