616883-46-6Relevant academic research and scientific papers
Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates
Sun, Chengzao,Wirsching, Peter,Janda, Kim D.
, p. 2213 - 2215 (2002)
A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFv
Enabling ScFvs as multi-drug carriers: A dendritic approach
Sun, Chengzao,Wirsching, Peter,Janda, Kim D.
, p. 1761 - 1768 (2007/10/03)
To enable scFvs as multi-drug carriers, we designed and synthesized dendritic linker molecules bearing up to nine chlorambucil residues at the branch ends. A maleimide group was used at the focal point of the dendron for easy linkage to the scFv. Original
