1346746-81-3Relevant articles and documents
Synthetic method of phenylethanolamine A
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, (2019/05/28)
The invention discloses a method for preparing phenylethanolamine A. The method includes the following steps: 1) reacting p-methoxyacetophenone in an HBr/DMSO system to obtain acetophenone aldehyde monohydrate and acetophenone aldehyde; 2) subjecting the acetophenone aldehyde and 4(4-nitrophenyl)butane-2-amine to bimolecular substitution reaction, and subjecting an intermediate product obtained bythe reaction to reduction reaction by potassium borohydride to obtain the phenylethanolamine A. The method has the advantages that the reactions are simple, the reaction steps are reduced, and the high-yield phenylethanolamine A is obtained.
Method for preparing phenylethanolamine compound intermediate
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, (2018/05/07)
The invention discloses a method for preparing a phenylethanolamine compound intermediate. The method comprises the following steps: (1) carrying out a nitrifying reaction on 1-methyl-3-phenylpropylamine and a nitrifying reagent to obtain a 4-(4-nitrophenyl)-butan-2-amine and 4-(2-nitrophenyl)-butan-2-amine mixture; and (2) reacting the mixture obtained in step (1) with a compound of formula III,and separating the obtained reaction product to obtain the phenylethanolamine compound intermediate of formula I. The method for preparing the phenylethanolamine compound intermediate has the advantages of simplicity in operation, short route and few steps; and an o-nitro impurities generated in the nitrifying reaction can be easily removed after being reacted without separation and becoming corresponding amides, so the reaction yield and the product purity are high, and the industrial production of the product is facilitated.