61714-42-9

Usage

Uses

Used in Organic Synthesis:
6-[(phenylsulphonyl)amino]hexanoic acid is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different properties and functions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 6-[(phenylsulphonyl)amino]hexanoic acid is utilized as a key component in drug design. 6-[(phenylsulphonyl)amino]hexanoic acid's ability to interact with biological systems makes it a promising candidate for the development of new medications.
Used in Drug Design and Delivery:
6-[(phenylsulphonyl)amino]hexanoic acid is used as a component in drug design for its lipophilic properties, which can enhance the drug's absorption, distribution, metabolism, and excretion (ADME) profile. Additionally, it may be employed in drug delivery systems to improve the efficacy and targeting of therapeutic agents.
Used in the Treatment of Diseases and Disorders:
Although further research is needed, 6-[(phenylsulphonyl)amino]hexanoic acid shows potential for use in the treatment of various diseases and disorders. Its interaction with biological systems suggests that it may have therapeutic effects in conditions that are yet to be fully explored.

InChI:InChI=1/C12H17NO4S/c14-12(15)9-5-2-6-10-13-18(16,17)11-7-3-1-4-8-11/h1,3-4,7-8,13H,2,5-6,9-10H2,(H,14,15)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 60-32-2 6-aminohexanoic acid 
• 2780-89-4 methyl 6-aminohexanoate hydrochloride 

Downstream Products

• 70034-77-4 6-benzenesulfonylamino-hexanoic acid amide 
• 61714-43-0 N-(5-Amino-pentyl)-benzenesulfonamide; hydrochloride 

Relevant academic research and scientific papers

PROTEASOME INHIBITORS AND METHODS OF USING THE SAME

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Compounds and compositions for delivering active agents

The present invention provides a compound having the formula or a salt thereof which facilitates the delivery of active agents. Compositions and dosage unit forms comprising the compound of the present invention and at least one active agent, such as a peptide, mucopolysaccharide, carbohydrate, or a lipid, are also provided. Methods of administration and preparation of the compounds and compositions of the invention are provided as well.

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

FTIR Spectral Study of Intramolecular Hydrogen Bonding in Thromboxane A2 Receptor Antagonist S-145 and Related Compounds. 3. Conformation and Activity of S-145 Analogues

S-145, (+/-)-(5Z)-7-bicyclohept-2-exo-yl>heptenoic acid, its chain analogues HO2C(CH2)nNHSO2Ph (n=3-8,10, and 11) 1-8, and (5Z)-9-(phenylsulfonyl)aminonon-5-enoic acid (9) were synthesized in order to elucidate the dependence of the conformation in solution and of the pharmacological activity on the side-chain length.Their FTIR spectra were measured in dilute CCl4 solution.Tor these compounds, intramolecular hydrogen bonds similar to those observed for S-145 were found between the carboxyl and sulfonamido groups.A linear relationship was also found between the percentage (ρ) of the intramolecular hydrogen-bonded molecules and the n value.Compounds 1-9 were examined in vitro for inhibitory concentrations (IC50) against U-46619- and collagen-induced aggregations for rabbit and rat washed platelets (WP), respectively, and U-46619-induced contraction for rat aorta.Three kinds of TXA2 receptor antagonistic potencies showed parabolic correlations with the n value, though the ρ value was in direct proportion to the n value.The log (1/IC50) values for 6 (n=8), which forms a 12-membered ring similar to the one observed for S-145, were found to be maximal values in 1-8 and were comparable to those for BM-13177.In compounds 9 (ρ = 83percent) and S-145 (ρ = 89percent), the IC50 values of 41 and 2.9 nM for rat WP were 10 and 141 times lower than that of 6 (ρ = 52percent), respectively.In these compounds, which form the 12-membered ring, the inhibitory potencies increase as the ρ value increases.

SYNTHESIS OF ALIPHATIC AMINES RELATED TO MONODANSYLCADAVERINE VIA THE OXIDATIVE REARRANGEMENT OF ALIPHATIC AMIDES WITH PHENYL IODOSYL BIS(TRIFLUOROACETATE)

A series of aliphatic primary amides have been oxidatively rearranged to primary amines with phenyl iodosyl(trifluoroacetate).Sulfonamide groups on the substrates have not been affected.