6173-64-4

Basic information

• Product Name: 17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one
• Synonyms: 17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one
• CAS NO: 6173-64-4
• Molecular Formula: C₂₃H₃₂O₅
• Molecular Weight: 388.49718
• Mol File: 6173-64-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: DCM, Ethyl Acetate, Methanol
• CAS DataBase Reference: 17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one(6173-64-4)
• EPA Substance Registry System: 17,20:20,21-Bis(Methylenedioxy)pregn-4-en-3-one(6173-64-4)

Safety Data

• Hazardous Substances Data: 6173-64-4(Hazardous Substances Data)

Usage

Uses

17,20:20,21-Bis(methylenedioxy)pregn-4-en-3-one is an intermediate in the synthesis of metabolites of Cortisol (H714615).

Upstream product

• 50-00-0 formaldehyd 
• 152-58-9 Cortexolone 

Downstream Products

• 1415087-38-5 [2,2,α3,4,4-d5]-17,20;20,21-bismethylenedioxy-5α-pregnan-3β-yl p-toluenesulfonate 
• 1415087-36-3 17,20;20,21-bismethylenedioxy-5α-pregnan-3β-yl ptoluenesulfonate 

Relevant articles and documents

Synthesis of 3- and 21-monosulfates of [2,2,3β,4,4-2H 5]-tetrahydrocorticosteroids in the 5β-series as internal standards for mass spectrometry

The 3- and 21-monosulfates of pentadeuterated 5β- tetrahydrocorticosteroides were synthesized, starting from cortisol and 11-deoxycotisol. The principal reactions used were (1) perdeuteration of the methylene groups adjacent to the 3-oxo group of 17,20:20,21-bismethylendioxy- 5β-3-ketosteroids with NaOD in CH3OD followed by stereoselective reduction with NaBD4, (2) sulfation of hydroxy groups with sulfur trioxide-trimethylamine complex, and (3) removal of the 17,20:20,21- bismethylendioxy group with hydrogen fluoride. The labeled compounds can be used as internal standards in liquid chromatography/mass spectrometry assays for clinical and biochemical studies.