61736-36-5

Usage

Uses

Used in Pharmaceutical Industry:
2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-phenylis used as a building block for the synthesis of various pharmaceutical compounds. Its unique structural features and potential biological activities make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-phenylmay be utilized as a precursor or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its structural properties and potential biological activities can contribute to the development of more effective and targeted agrochemical products.
Used in Materials Science:
2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-phenylcan also be employed in materials science for the development of novel materials with specific properties. Its heterocyclic structure and functional groups may be integrated into the design of advanced materials for various applications, such as sensors, catalysts, or optoelectronic devices.

Upstream product

• 13345-09-0 6-phenyluracil 
• 412338-87-5 3-methyl-6-phenyl-dihydro-pyrimidine-2,4-dione 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 598-50-5 N-Methylurea 
• 74303-68-7 3-methyl-2-(methylsulfanyl)-6-phenylpyrimidin-4(3H)-one 
• 590-28-3 potassium cyanate 
• 36822-11-4 6-phenyl-2-thiouracil 
• 4318-56-3 3-methyl-6-chlorouracil 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells

Signal transducer and activator of transcription 3 (STAT3) is a tumorigenic transcription factor that is persistently activated in various human cancers including hepatocellular carcinoma (HCC). Therefore, STAT3 is considered as a prominent target to counteract the uncontrolled proliferation of cancer cells. In the present report, pyrimidine-2,4-diones (N-methyluracil derivatives) (MNK1-MNK14) were synthesized in an ionic liquid (BMIm PF6) medium employing a ligand-free Suzuki-Miyaura cross-coupling process. Among the 14 derivatives, compound MNK8 showed good cytotoxicity towards both the tested cell lines and did not display a toxic effect against normal hepatocytes (LO2). MNK8 significantly increased the Sub-G1 cell count in both cell lines and the cytotoxic effect of MNK8 was found to be mediated through the suppression of constitutive phosphorylation of STAT3Y705. It also decreased the DNA interaction ability of nuclear STAT3 in HCC cells. MNK8 downregulated the levels of apoptosis-related proteins (such as Bcl-2, cyclin D1, survivin) and increased cleaved caspase-3 inferring the apoptogenic effect of MNK8. It also reduced the CXCL12-triggered cell migration and invasion in in vitro assay systems. Overall, MNK8 has been demonstrated as a new inhibitor of STAT3 signaling cascade in HCC cells.

Direct Chemoselective Synthesis of N-3-Substituted Pyrimidinones in a Microwave-Assisted Method

Synthesis of selectively N-3-substituted pyrimidine nucleobases or pyrimidinones has always been a challenge because of poor regioselectivity and chemoselectivity. In this article we demonstrate a single-step, de novo synthesis of selectively N-3-substitu

Synthesis of uracil derivatives by oxidation of Fischer tungsten-carbene uracil complexes

A study on the oxidation of Fischer tungsten-carbene uracil complexes has been carried out. Several commonly used oxidants gave results strongly influenced by the presence of substituent on nitrogen atoms. In particular, usual oxidants failed in the oxidation of 3-alkyl uracil carbene complexes. Finally, we showed that t-butyl hydroperoxide is able to oxidize successfully also 3-alkyl uracil carbene complexes and can be used as a good alternative to the other methods.