61752-45-2

Upstream product

• 76620-28-5 5-phenylpent-2-yn-5-one 
• 106944-46-1 3-Hydroxy-4-trimethylsilyl-1-phenyl-1-pentanone 
• 3240-29-7 1-Phenylpent-4-en-1-one 
• 96-09-3 styrene oxide 
• 4885-09-0 1-phenyl-3-pentyn-1-ol 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 84066-63-7 2-(2-propynyl)-2-phenyl-1,3-dithiane 
• 84066-64-8 1-phenyl-1-(2-butynyl)dithiane 
• 698-16-8 benzohydroximoyl chloride 
• 869572-67-8 2-(1-hydroxyethyl)-1-phenylcyclopropanol 
• 75-11-6 diiodomethane 
• 73172-59-5 [(2RS,3SR)-3-methyloxiran-2-yl]phenylmethanone 
• 4784-77-4 (E/Z)-crotyl bromide 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 

Downstream Products

• 76620-30-9 endo-3-phenyl-6-methyl-1,2-diazabicyclo<3.1.0>hex-2-ene 
• 76620-30-9 exo-3-phenyl-6-methyl-1,2-diazabicyclo<3.1.0>hex-2-ene 
• 76620-30-9 endo-3-phenyl-6-methyl-1,2-diazabicyclo<3.1.0>hex-3-ene 
• 76633-73-3 exo-6-methyl-3-phenyl-1,2-diazabicyclo<3.1.0>hex-2-ene 
• 76620-29-6 ((Z)-1-Diazo-pent-3-enyl)-benzene 
• 61752-66-7 (E)-1-phenyl-2-penten-1-one 
• 76620-27-4 cis-1-phenyl-3-penten-1-one N-tosylhydrazone 

Relevant academic research and scientific papers

Prins cyclization of α-bromoethers under basic conditions

α-Bromoethers have been found to undergo Prins-type cyclization under basic conditions and without the need to add a promoter. The products are those derived from a Markovnikov addition on the pendant alkene. However, the stereochemistry and even the structure of the products sometimes differ from those expected with the classical Lewis-acid-catalyzed Prins reaction of acetals.

A new zincate-mediated rearrangement reaction of 2-(1-hydroxyalkyl)-1- alkylcyclopropanol

A novel rearrangement of 2-(1-hydroxyalkyl)-1-alkylcyclopropanol has been found. It proceeds in the presence of a catalytic amount of organozinc ate complex to give vic-diols. The rearrangement can be applied to various types of 2-(1-hydroxyalkyl)-1-alkyl-cyclopropanol, which can be easily prepared from the corresponding α,β-ep-oxyketones and bis(iodozincio)methane. When bicyclo[13.1.0]-pentadecane-1, 15-diol was treated with the organozinc ate complex, the corresponding 14-membered cyclic vic-diol was obtained. Thus, this rearrangement is also useful for changing the ring size of cyclic substrates.

Stereoselective synthesis of β,γ-unsaturated ketones by acid-mediated Julia-type transformation from 2-(1-hydroxyalkyl)-1- alkylcyclopropanols

An efficient transformation of 2-(1-hydroxyalkyl)-1-alkylcyclopropanols, obtained from α,β-unsaturated ketones, to β,γ-unsaturated ketones was achieved by trifluoroacetic acid (TFA)-mediated reaction. Georg Thieme Verlag Stuttgart.

Reduction of 4,5-Dihydro-1,2-oxazoles (Δ2-Isoxazolines); A Cycloadditive Approach to 2-Alkenyl Ketones

A new cycloadditive route to 2-alkenyl ketones (β,γ-unsaturated ketones) involves: (1) nitrile oxide-allylsilane (or stannane) cycloaddition, (2) reductive cleavage of the resultant isoxazoline, and (3) Peterson elimination.In all cases, the products are not contaminated by the isomeric 1-alkenyl ketones.Although stereoselectivity in the nitrile oxide cycloaddition to 3-trimethylsilyl-1-butene is low, the resultant diastereomeric cycloadducts can be converted stereospecifically to the corresponding (E)- and (Z)-olefins.