61752-66-7

Upstream product

• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 925-90-6 ethylmagnesium bromide 
• 123-38-6 propionaldehyde 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 61752-45-2 Z-1-phenylpent-3-en-1-one 
• 1588-56-3 trans-2-phenyl-1-ethylcyclopropane 
• 4250-81-1 1-phenyl-1-pentyne 
• 61836-09-7 2-Methylsulfanyl-1-phenyl-pentan-1-one 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 6048-29-9 triphenylphenacylphosphonium bromide 

Downstream Products

• 1008533-99-0 C₂₂H₃₄OSi 
• 61831-63-8 2-phenyl-3-n-propylquinoline 
• 1033065-00-7 tert-butyl benzyloxy(1-oxo-1-phenylpentan-3-yl)carbamate 
• 1015421-33-6 (E)-4-phenyl-1,5-octadien-4-ol 
• 1357026-74-4 C₂₂H₃₄OSi 
• 1360472-50-9 (R)-2-ethyl-4-oxo-4-phenylbutanenitrile 
• 1360472-47-4 (S)-2-ethyl-4-oxo-4-phenylbutanenitrile 
• 1360472-69-0 C₁₂H₁₅NO₂ 
• 1360472-70-3 C₁₂H₁₄N₂O 

Relevant academic research and scientific papers

Method for preparing phenyl propenone compound by catalyzing phenylacetylene through molecular sieve

The invention belongs to the field of molecular sieve catalysis and organic synthesis, and discloses a method for preparing a phenyl propenone compound by catalyzing phenylacetylene through a molecular sieve, which comprises the following steps: adding a phenylacetylene compound I, aldehyde II and a molecular sieve catalyst into a small reaction kettle without adding an organic solvent and any other assistants; performing stirring to react for 0.25-6 hours under the condition of heating at 30-90 DEG C, cooling the reaction kettle to room temperature, performing diluting with ethyl acetate, andcentrifugally separating the catalyst to obtain the phenyl allyl ketone compound III. The molecular sieve catalyst provided by the invention is H-beta of which the silica-alumina ratios are respectively 14 and 29. The method is simple in reaction process, high in catalytic activity and selectivity, recyclable, environmentally friendly and capable of achieving large-scale industrial production.

Nickel-catalyzed remote hydrosilylation of unconjugated enones with bulky triphenylsilane

Herein we describe a nickel-catalyzed remote hydrosilylation of unconjugated enones with bulky triphenylsilane. A range ofZ-silyl enol ethers are obtained as major isomers due to the process of nickel triggered alkene isomerization. Notably, some specific

GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes

GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated as a potential drug target of Huntington's disease (HD), an incurable monogenic neurodegenerative disorder. In this research, we found that striatal knockdown of GPR52 reduces mHTT levels in adult HdhQ140 mice, validating GPR52 as an HD target. In addition, we discovered a highly potent and specific GPR52 antagonist Comp-43 with an IC50 value of 0.63 μM by a structure-activity relationship (SAR) study. Further studies showed that Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Moreover, in vivo study showed that Comp-43 not only reduces mHTT levels but also rescues HD-related phenotypes in HdhQ140 mice. Taken together, our study confirms that inhibition of GPR52 is a promising strategy for HD therapy, and the GPR52 antagonist Comp-43 might serve as a lead compound for further investigation.

Organocatalytic Enantioselective Selenosulfonylation of a C-C Double Bond to Form Two Stereogenic Centers in an Aqueous Medium

Organocatalytic selenosulfonylation of the C-C double bond of α,β-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of α-selenyl and β-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.

Oxazolium Salts as Organocatalysts for the Umpolung of Aldehydes

Oxazolium salts were successfully employed for the first time as organocatalysts for benzoin, Stetter, and redox esterification reactions. An N-mesityl oxazolium salt catalyzed homobenzoin reaction of aromatic, heteroaromatic, and aliphatic aldehydes delivered α-hydroxy ketones in high yields. This new type of catalyst proved remarkably effective for the Stetter reaction of challenging substrates such as β-alkyl-α,β-unsaturated ketones and electron-rich aromatic aldehydes in comparison to common thiazolium and triazolium salts.

Solvent free, light induced 1,2-bromine shift reaction of α-bromo ketones

Photolysis of α-bromopropiophenones in acetonitrile results in formation of β-bromopropiophenones with good product selectivity, which can be coined as 1,2-Br shift reaction. The product selectivity increases when the reaction is done in neat or solid state, where only the 1,2-Br shift product is formed in some cases. The reaction is suggested to proceed by C–Br bond homolysis to give a radical pair, followed by disproportionation and conjugate addition of HBr to the α,β-unsaturated ketone intermediate. When the unsaturated intermediate is stabilized by an extra conjugation, the reaction stops at the stage, in which the unsaturated ketone becomes a major product. The synthetic method described in this research fits in a category of eco-friendly organic synthesis nicely since the reaction does not use volatile organic solvents and any other additives such as acid, base or metal catalysts, etc. Besides, the method fits into perfect atom economy, which does not give any side products. The synthetic method should find much advantage over other alternative methods to obtain β-bromo carbonyl compounds.

Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes

A general, efficient and economic palladium-catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand-free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late-stage synthesis of natural products, pharmaceuticals and fine chemicals. (Figure presented.).

An iron-catalyzed hydroalkylation reaction of α,β-unsaturated ketones with ethers

A general strategy for the hydroalkylation of vinyl ketones using ethers catalyzed by an iron catalyst is described. This catalytic method permits direct transformation of easily accessible and abundant precursors into highly substituted, structurally diverse and functionally concentrated products.

Palladium(II)-Catalyzed Dehydroboration via Generation of Boron Enolates

The PdII-catalyzed dehydroboration of boron enolates generated from ketones and 9-iodo-9-borabicyclo[3.3.1]nonane was achieved, providing a synthetically versatile protocol from ketones to α,β-unsaturated ketones. The PdIIcompound employed in this reaction worked catalytically in the presence of Cu(OAc)2. The high trans-selectivity of the olefinic moiety was observed. Aryl halide moieties (-Br and -Cl) remained intact for this reaction in spite of the presence of a Pd species. An ester substrate could also be applied when a stoichiometric amount of PdIIwas used. The crossover reactions using boron and silyl enolates revealed that the oxidation reaction is much faster than the Saegusa-Ito reaction.

A convenient synthesis of 4-alkyl-3-benzoylpyrroles from α,β-unsaturated ketones and tosylmethyl isocyanide

A convenient synthesis of 4-alkyl-3-benzoyl pyrrole was achieved from α,β-unsaturated ketones and tosylmethyl isocyanide in the presence of mild base LiOH·H2O. This method is very economical and was successfully utilized for the synthesis of various 4-alkyl-3-benzoylpyrrole derivatives with good to excellent yields.