61752-66-7

Basic information

• Product Name: 2-Penten-1-one, 1-phenyl-, (2E)-
• Synonyms: (E)-1-phenyl-pent-2-en-1-on;1-phenyl-2-penten-1-one;(E)-1-phenyl-2-penten-1-one;phenyl butenyl ketone;(E)-1-phenylpent-2-en-1-one
• CAS NO: 61752-66-7
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 61752-66-7.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: 2-Penten-1-one, 1-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Penten-1-one, 1-phenyl-, (2E)-(61752-66-7)
• EPA Substance Registry System: 2-Penten-1-one, 1-phenyl-, (2E)-(61752-66-7)

Safety Data

• Hazardous Substances Data: 61752-66-7(Hazardous Substances Data)

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 123-38-6 propionaldehyde 
• 70-11-1 α-bromoacetophenone 
• 536-74-3 phenylacetylene 
• 49851-31-2 α-bromovalerophenone 
• 98-86-2 acetophenone 
• 61836-09-7 2-Methylsulfanyl-1-phenyl-pentan-1-one 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 925-90-6 ethylmagnesium bromide 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 6048-29-9 triphenylphenacylphosphonium bromide 

Downstream Products

• 76886-34-5 3-phenylmethoxy-1-phenyl-1-propanone 
• 1008533-99-0 C₂₂H₃₄OSi 
• 1015421-33-6 (E)-4-phenyl-1,5-octadien-4-ol 
• 1360472-50-9 (R)-2-ethyl-4-oxo-4-phenylbutanenitrile 
• 1360472-47-4 (S)-2-ethyl-4-oxo-4-phenylbutanenitrile 
• 1360472-69-0 C₁₂H₁₅NO₂ 
• 1360472-70-3 C₁₂H₁₄N₂O 
• 1009-14-9 phenyl butyl ketone 

Relevant articles and documents

GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes

GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated as a potential drug target of Huntington's disease (HD), an incurable monogenic neurodegenerative disorder. In this research, we found that striatal knockdown of GPR52 reduces mHTT levels in adult HdhQ140 mice, validating GPR52 as an HD target. In addition, we discovered a highly potent and specific GPR52 antagonist Comp-43 with an IC50 value of 0.63 μM by a structure-activity relationship (SAR) study. Further studies showed that Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Moreover, in vivo study showed that Comp-43 not only reduces mHTT levels but also rescues HD-related phenotypes in HdhQ140 mice. Taken together, our study confirms that inhibition of GPR52 is a promising strategy for HD therapy, and the GPR52 antagonist Comp-43 might serve as a lead compound for further investigation.

Method for preparing phenyl propenone compound by catalyzing phenylacetylene through molecular sieve

The invention belongs to the field of molecular sieve catalysis and organic synthesis, and discloses a method for preparing a phenyl propenone compound by catalyzing phenylacetylene through a molecular sieve, which comprises the following steps: adding a phenylacetylene compound I, aldehyde II and a molecular sieve catalyst into a small reaction kettle without adding an organic solvent and any other assistants; performing stirring to react for 0.25-6 hours under the condition of heating at 30-90 DEG C, cooling the reaction kettle to room temperature, performing diluting with ethyl acetate, andcentrifugally separating the catalyst to obtain the phenyl allyl ketone compound III. The molecular sieve catalyst provided by the invention is H-beta of which the silica-alumina ratios are respectively 14 and 29. The method is simple in reaction process, high in catalytic activity and selectivity, recyclable, environmentally friendly and capable of achieving large-scale industrial production.

Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes

A general, efficient and economic palladium-catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand-free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late-stage synthesis of natural products, pharmaceuticals and fine chemicals. (Figure presented.).