617673-38-8

Upstream product

• 552890-48-9 Acetic acid (2S,3S)-3-((2S,3R,4aS,6S,9S,9aR)-2-allyl-9-benzenesulfonylmethyl-3-benzyloxy-3,4,4a,6,9,9a-hexahydro-2H-1,5-dioxa-benzocyclohepten-6-yl)-1-((S)-2-benzyloxy-3-hydroxy-propyl)-2-methyl-butyl ester 
• 50272-15-6 methyl 2-O-benzyl-3,6-dideoxy-α-D-ribo-hexopyranoside 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 15354-29-7 methyl 4,6-O-isopropylidene-α-D-glucopyranoside 
• 552890-56-9 (4aR,6S,7R,8aS)-6-Methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 552890-29-6 2,2-Dimethyl-propionic acid (4aR,6S,7R,8aS)-6-methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 104652-29-1 2,2-Dimethyl-propionic acid (4aR,6S,7R,8S,8aS)-8-hydroxy-6-methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 552890-59-2 (2R,3S,5R,6S)-6-Allyl-5-benzyloxy-2-hydroxymethyl-tetrahydro-pyran-3-ol 
• 552890-57-0 2,2-Dimethyl-propionic acid (2R,3S,5R,6R)-6-acetoxy-5-benzyloxy-2-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester 
• 552890-58-1 2,2-Dimethyl-propionic acid (2R,3S,5R,6S)-5-benzyloxy-2-(2,2-dimethyl-propionyloxymethyl)-6-hydroxy-tetrahydro-pyran-3-yl ester 
• 100-44-7 benzyl chloride 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 617673-33-3 2,2-Dimethyl-propionic acid (2R,3S,5R)-6-acetoxy-5-benzyloxy-2-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester 

Downstream Products

• 552890-55-8 C₃₅H₄₆O₈ 
• 552890-54-7 C₄₁H₅₀O₁₀S 
• 552890-50-3 (2S,5S,6S)-6-((2S,3R,4aS,6S,9S,9aR)-2-Allyl-9-benzenesulfonylmethyl-3-benzyloxy-3,4,4a,6,9,9a-hexahydro-2H-1,5-dioxa-benzocyclohepten-6-yl)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-5-methyl-heptan-4-one 
• 552890-51-4 (2S,5S,6S)-6-[(2S,3R,4aS,6S,9S,9aR)-9-Benzenesulfonylmethyl-3-benzyloxy-2-(2-oxo-propyl)-3,4,4a,6,9,9a-hexahydro-2H-1,5-dioxa-benzocyclohepten-6-yl]-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-5-methyl-heptan-4-one 
• 552890-65-0 (2S,5S,6S)-6-((2S,3R,4aS,6S,9S,9aR)-2-Allyl-9-benzenesulfonylmethyl-3-benzyloxy-3,4,4a,6,9,9a-hexahydro-2H-1,5-dioxa-benzocyclohepten-6-yl)-2-benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-5-methyl-heptan-4-ol 

Relevant academic research and scientific papers

Synthesis of the JKLM-ring fragment of ciguatoxin

A stereoselective synthesis of the LM-ring fragment has been achieved starting from a sugar derivative. A stereoselective synthesis of the JKLM-ring fragment has been achieved through a coupling between two segments via heteroconjugate addition, seven-membered ether ring formation mediated by an acetylene cobalt complex, and spiroketalization reaction.

Synthesis of JKLM ring fragment of ciguatoxin via acetylene-cobalt strategy

A stereoselective synthesis of the JKLM ring fragment has been achieved through a coupling between two segments via heteroconjugate addition, seven-membered ether ring formation mediated by an acetylene cobalt complex and spiroketalization reaction.