6178-42-3

Basic information

• Product Name: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE
• Synonyms: 3-METHOXY-4-HYDROXY-BETA-NITROSTYRENE;4-HYDROXY-3-METHOXY-BETA-NITROSTYRENE, >95%;1-(2-Nitroethenyl)-3-methoxy-4-hydroxybenzene;2-Methoxy-4-(2-nitroethenyl)phenol;β-Nitro-3-methoxy-4-hydroxystyrene;2-Methoxy-4-[(E)-2-nitrovinyl]phenol 98%;trans-4-Hydroxy-3-methoxy-beta-nitrostyrene, 2-Hydroxy-5-[(E)-2-nitroethenyl]anisole;trans-4-Hydroxy-3-methoxy-beta-nitrostyrene 98%
• CAS NO: 6178-42-3
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17
• Product Categories: Ethanes/ethenes;Acyclic;Alkenes;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;H;Organic Building Blocks
• Mol File: 6178-42-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 168-170 °C(lit.)
• Boiling Point: 347°C at 760 mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.308g/cm³
• Vapor Pressure: 2.77E-05mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 8.09±0.18(Predicted)
• CAS DataBase Reference: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE(6178-42-3)
• EPA Substance Registry System: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE(6178-42-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 6178-42-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Different sources of media describe the Uses of 6178-42-3 differently. You can refer to the following data:
1. β-Nitrostyrene derivative, with inhibitory activity of Src and/or Syk kinase and antibacterial activity.
2. trans-4-Hydroxy-3-methoxy-β-nitrostyrene may be used in the synthesis of cytotoxic β-nitrostyrene derivatives, 4-O-benzoyl-3-methoxy-β-nitrostyrene (BMNS) derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2781, 1950 DOI: 10.1021/ja01162a521

General Description

trans-4-Hydroxy-3-methoxy-β-nitrostyrene is a phenolic β-nitrostyrene. Synthesis of 4-hydroxy-3-methoxy-β-nitrostyrene is reported.

InChI:InChI=1/C9H9NO4/c1-14-9-6-7(2-3-8(9)11)4-5-10(12)13/h2-6,11H,1H3/b5-4+

Upstream product

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Relevant articles and documents

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