618095-48-0

Basic information

• Product Name: γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate
• Synonyms: γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate
• CAS NO: 618095-48-0
• Molecular Weight: 342.306
• Mol File: 618095-48-0.mol

Chemical Properties

• CAS DataBase Reference: γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate(618095-48-0)
• EPA Substance Registry System: γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate(618095-48-0)

Safety Data

• Hazardous Substances Data: 618095-48-0(Hazardous Substances Data)

Upstream product

• 53413-67-5 6-nitroveratrylbromide 
• 56-86-0 L-glutamic acid 
• 618095-50-4 N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid tert-butyl ester 
• 24277-39-2 N-tert-butoxycarbonyl glutamic acid tert-butyl ester 

Downstream Products

• 1380074-42-9 γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamic acid N-carboxyanhydride 

Relevant articles and documents

Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: Toward nonviral gene delivery

Gene delivery vehicles: Helical, cationic polypeptides with light-responsive domains showed potent membrane activity and promoted efficient cellular internalization of DNA (see picture). After transfection, a light trigger induces protecting-group removal to expose anionic carboxylate groups. The reduced cationic charge and helix distortion of the polypeptides result in enhanced DNA unpacking and reduced material toxicity because of the eliminated membrane activity. Copyright

STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF MAKING AND USING SAME

Stimuli-switchable moieties, monomers incorporating stimuli-switchable moieties, and polymers incorporating such stimuli-switchable moieties are provided. The stimuli-switchable moiety can be a pyrano aryl chromenone-derivative. The stimuli-switchable monomer can be a lactone monomer. The stimuli-switchable monomer can be an amino acid, which can be incorporated into a specific peptide sequence by peptide synthesis.

Stable helical ionic polypeptides

The invention provides polymers comprising Formula I: wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally

Polypeptide vesicles with densely packed multilayer membranes

Multilamellar membranes are important building blocks for constructing self-assembled structures with improved barrier properties, such as multilamellar lipid vesicles. Polymeric vesicles (polymersomes) have attracted growing interest, but multilamellar polymersomes are much less explored. Here, we report the formation of polypeptide vesicles with unprecedented densely packed multilayer membrane structures with poly(ethylene glycol)-block-poly(γ-(4,5-dimethoxy-2-nitrobenzyl)-l-glutamate) (PEG-b-PL), an amphiphilic diblock rod-coil copolymer containing a short PEG block and a short hydrophobic rod-like polypeptide segment. The polypeptide rods undergo smectic ordering with PEG buried between the hydrophobic polypeptide layers. The size of both blocks and the rigidity of the hydrophobic polypeptide block are critical in determining the membrane structures. Increase of the PEG length in PEG-b-PL results in the formation of bilayer sheets, while using random-coil polypeptide block leads to the formation of large compound micelles. UV treatment causes ester bond cleavage of the polypeptide side chain, which induces helix-to-coil transition, change of copolymer amphiphilicity, and eventual disassembly of vesicles. These polypeptide vesicles with unique membrane structures provide a new insight into self-assembly structure control by precisely tuning the composition and conformation of polymeric amphiphiles.