61810-78-4 Usage
Uses
Used in Pharmaceutical Industry:
(2S)-1-Methyl-2-Pyrrolidineethanol is used as a racemate to study the enzyme activity of cytochrome P450 2C19, which is crucial for understanding drug metabolism and the efficacy of various medications.
Used in Hemodialysis:
(2S)-1-Methyl-2-Pyrrolidineethanol may be used as a hemodialysis agent, potentially aiding in the treatment of patients with kidney diseases by facilitating the removal of waste products from the blood.
Used in Antitussive Applications:
The (2S) enantiomer of (2S)-1-Methyl-2-Pyrrolidineethanol is used as an antitussive agent, helping to suppress coughing by reducing the irritation in the throat and respiratory tract.
Used in Expectorant Applications:
As an expectorant, the (2S) enantiomer aids in thinning and loosening mucus in the respiratory tract, making it easier to expel through coughing.
Used in Antiasthmatic Applications:
The (2S) enantiomer also serves as an antiasthmatic agent, potentially helping to reduce inflammation and constriction in the airways, thereby alleviating symptoms of asthma.
Check Digit Verification of cas no
The CAS Registry Mumber 61810-78-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,8,1 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61810-78:
(7*6)+(6*1)+(5*8)+(4*1)+(3*0)+(2*7)+(1*8)=114
114 % 10 = 4
So 61810-78-4 is a valid CAS Registry Number.
61810-78-4Relevant academic research and scientific papers
Synthesis of (-)-(S, S)-clemastine by invertive N → C aryl migration in a lithiated carbamate
Fournier, Anne M.,Brown, Robert A.,Farnaby, William,Miyatake-Ondozabal, Hideki,Clayden, Jonathan
supporting information; experimental part, p. 2222 - 2225 (2010/08/04)
The first enantioselective synthesis of the antihistamine agent clemastine, as its (S,S)-stereoisomer, has been achieved by ether formation between a proline-derived chloroethylpyrrolidine and an enantiomerically enriched tertiary alcohol. The tertiary alcohol was formed from the carbamate derivative of α-methyl-p-chlorobenzyl alcohol by invertive aryl migration on lithiation. The (S,S)-stereochemistry of the product confirms the invertive nature of the rearrangement.
LIGAND EFFECTS IN ENANTIOFACE DIFFERENTIATING 1,4 ADDITION TO 1,3 DIPHENYL-2 PROPEN-1 ONE
Leyendecker, Francois,Jesser, Francis,Laucher, Dominique
, p. 3513 - 3516 (2007/10/02)
The extent of enantiomeric excess in the β-methylation of chalcone by chiral cuprates is shown to depend strongly on small structural modifications of the ligands, all of which are derived from the basic carbon framework of L-prolinol.Enantiomeric excesses up to 88percent have been realised.
