618120-18-6

Basic information

• Product Name: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol
• Synonyms: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol
• CAS NO: 618120-18-6
• Molecular Weight: 374.521
• Mol File: 618120-18-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol(618120-18-6)
• EPA Substance Registry System: (1S,2S)-1-hydroxymethyl-2-[(2S)-2-(5-methoxy-2,7-dimethyl-2H-chromen-2-yl)ethyl]-3,3-dimethylcyclohexanol(618120-18-6)

Safety Data

• Hazardous Substances Data: 618120-18-6(Hazardous Substances Data)

Upstream product

• 1092965-13-3 3-methoxy-5-methyl-2-(3-methyl-but-3-enyl)-phenol 
• 61175-92-6 3,3-dimethyl-1-<(trimethylsilyl)oxy>cyclohex-1-ene 
• 1193-18-6 3-methylcyclohexen-2-one 
• 74-88-4 methyl iodide 
• 35334-36-2 (+)-siccanochromene F 
• 1634-34-0 2',6'-dihydroxy-4'-methylacetophenone 
• 24190-33-8 (+)-(S)-dihydro-γ-ionone 
• 618120-15-3 (1S)-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)vinyl]-(2R)-5-methoxy-2,7-dimethylchroman 
• 593251-63-9 (E)-5-(2-hydroxy-6-methoxyphenyl)-3-methylpent-2-enyl methyl carbonate 

Downstream Products

• 22733-60-4 siccanin 
• 782474-51-5 Toluene-4-sulfonic acid (1S,2S)-1-hydroxy-2-[2-((S)-5-methoxy-2,7-dimethyl-2H-chromen-2-yl)-ethyl]-3,3-dimethyl-cyclohexylmethyl ester 

Relevant articles and documents

Formal Synthesis of (-)-Siccanin Using an Enantioselective Domino Wacker/Carbonylation/Methoxylation Reaction

A formal synthesis of (-)-siccanin was achieved through an enantioselective domino Wacker/carbonylation/methoxylation reaction as the key step to form the chroman ring with a quaternary stereogenic center with 95% ee. The pendant cyclohexyl moiety was introduced through a two-step aldol condensation.

Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations

(-)-Siccanin (1), a natural product possessing significant antifungal properties, was synthesized enantioselectively via a biomimetic route. This synthetic route features two sequential radical cyclizations: a Ti(III)-mediated radical cyclization of epoxy