61843-47-8Relevant academic research and scientific papers
Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO3
Lu, Lin,Luo, Chenguang,Peng, Hui,Jiang, Huanfeng,Lei, Ming,Yin, Biaolin
supporting information, p. 2602 - 2605 (2019/04/30)
A variety of structurally novel polycyclic sulfonyl indolines have been synthesized via FeCl2-catalyzed or UV-driven intramolecular formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methyl)propiolamides with NaHSO3 in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step.
A N - alkyl - 2 - aryl - indole - 3 - aldehyde synthesis method
-
Paragraph 0023; 0024; 0029; 0030; 0031, (2017/08/25)
The invention discloses a synthetic method for N-alkyl-2-aryl-indol-3-al and belongs to the technical field of chemical pharmacy and fine chemical preparation. Polysubstituted functionalized indole is an important organic compound. Metal-catalyzed sulfonyl triazole is decomposed into metal carbine, and the metal carbine produces a C-H bond insertion reaction for cyclization to obtain N-alkyl-2-aryl-indol-3-al, that is to say, a 1,2,3-trisubstituted indole structure. The method realizes effective synthesis of high-added-value cyclopropylazacyclo, provides a new technological route for preparing polysubstituted indole derivatives and can be widely applied to the field of chemical pharmacy and fine chemical engineering.
An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3-H bond insertion
Shen, Mei-Hua,Pan, Ying-Peng,Jia, Zhi-Hong,Ren, Xin-Tao,Zhang, Ping,Xu, Hua-Dong
, p. 4851 - 4854 (2015/05/05)
A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation. This journal is
Cu/Fe-cocatalyzed meyer-schuster-like rearrangement of propargylic amines: Direct access to e -β-aminoacryaldehydes
Chen, Ming,Peng, Jiangling,Mao, Tingting,Huang, Jinbo
supporting information, p. 6286 - 6289 (2015/02/05)
A simple and efficient method for the synthesis of β-aminoacryaldehydes via Cu(OAc)2·H2O and FeCl3 cocatalyzed Meyer-Schuster-Like rearrangement of propargylic amines was developed. The reactions proceed selectively as the E-isomers in generally good yields under aerobic conditions, and are compatible with a broad range of functional groups. This method combines C-N bond cleavage as well as the N-aryl group migration and provides a practical and mild synthetic approach to α,β-unsaturated carbonyl compounds, which are useful precursors in a variety of functional group transformations.
Palladium-catalyzed difunctionalization of alkynes via C-N and S-N cleavages: A versatile approach to highly functional indoles
Zhao, Fei,Zhang, Dengyou,Nian, Yong,Zhang, Lei,Yang, Wei,Liu, Hong
supporting information, p. 5124 - 5127 (2014/12/11)
Palladium-catalyzed intramolecular addition of C-N and S-N bond to alkynes with the migration of functional groups has been achieved. A wide range of functional groups including acyl, pyruvoyl, amide, and sulfonyl groups can migrate smoothly and be conveniently introduced at the C-3 postion of indoles in our catalytic system. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional indoles.
Direct transformation of N, N -dimethylformamide to -CN: Pd-catalyzed cyanation of heteroarenes via C-H functionalization
Ding, Shengtao,Jiao, Ning
supporting information; experimental part, p. 12374 - 12377 (2011/10/02)
This paper describes the direct cyanation of indoles and benzofurans employing N,N-dimethylformamide (DMF) as both reagent and solvent. Isotopic labeling experiments indicated that both the N and the C of the cyano group derived from DMF. This transformation offers an alternative method for preparing aryl nitriles, though it is currently limited in scope to indoles and benzofurans.
