618436-90-1

Upstream product

• 623-68-7 trans-crotonic anhydride 
• 168297-85-6 (S)-4-benzyl-5,5-dimethyloxazolidin-2-one 
• 63-91-2 L-phenylalanine 
• 170918-41-9 (S)-2-amino-3-phenyl-1,1-dimethylpropanol 
• 168297-81-2 N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide 
• 625-35-4 trans-chrotonyl chloride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 937204-13-2 C₁₈H₂₃NO₄ 
• 1197006-75-9 (2'S,2R,3S,4S)-{[3,4-dihydro-4-methyl-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-benzyl-3,3-dimethyloxazolidine 
• 168297-85-6 (S)-4-benzyl-5,5-dimethyloxazolidin-2-one 
• 937204-00-7 C₂₄H₃₉NO₄Si 
• 937203-99-1 C₂₄H₃₇NO₄Si 

Relevant academic research and scientific papers

Nitrile Ylides: Diastereoselective cycloadditions using chiral oxzolidinones without Lewis acid

"Chemical Equation Presented" Lewis acid complexation Is generally required for chiral-auxiliary-controlled stereoselectivity, and chiral Lewis acid catalysis Is frequently optimal for Introducing asymmetry. In this work, we show that nitrlle ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed In high yield and stereoselectivity in the absence of Lewis acids. In contrast, chiral Lewis acids are Inferior In these cycloadditions.

Stereocontrolled total synthesis of (-)-kainic acid

A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant