618460-98-3Relevant academic research and scientific papers
Design and synthesis of small chemical inhibitors containing different scaffolds for lck SH2 domain
Park, See-Hyoung,Kang, Sun-Hee,Lim, Sang-Hyeong,Oh, Hyun-Sik,Lee, Keun-Hyeung
, p. 3455 - 3459 (2003)
On the basis of the structure of (R)-rosmarinic acid, a series of small chemical compounds with a different scaffold was synthesized as inhibitors for lck SH2 domain. From ELISA results, most of all chemical compounds showed a similar or a little lower bi
Derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition
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Page/Page column 27-28, (2008/06/13)
The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphocyte by src homology region 2(SH2) domain of T lymphocyte (lck), so that they can be used for the treatment, prevention and/or diagnosis of graft rejection, autoimmune diseases, inflammatory diseases, etc.
Derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition
-
, (2008/06/13)
The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphocyte by src homology region 2(SH2) domain of T lymphocyte (lck), so that they can be used for the treatment, prevention and/or diagnosis of graft rejection, autoimmune diseases, inflammatory diseases, etc.
