618461-00-0

Upstream product

• 626201-05-6 (R)-2-(Benzhydryl-amino)-3-(3,4-dihydroxy-phenyl)-propionic acid methyl ester 
• 618460-98-3 methyl N-(diphenylmethylene)-D-3-hydroxytyrosine 
• 71855-43-1 (R)-(3,4-dihydroxyphenyl)alanine methyl ester 
• 5796-17-8 D-Dopa 
• 618460-99-4 methyl N-methyl-N(diphenylmethyl)-D-3-hydroxytyrosine 

Relevant academic research and scientific papers

Derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition

The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphocyte by src homology region 2(SH2) domain of T lymphocyte (lck), so that they can be used for the treatment, prevention and/or diagnosis of graft rejection, autoimmune diseases, inflammatory diseases, etc.

Design and synthesis of small chemical inhibitors containing different scaffolds for lck SH2 domain

On the basis of the structure of (R)-rosmarinic acid, a series of small chemical compounds with a different scaffold was synthesized as inhibitors for lck SH2 domain. From ELISA results, most of all chemical compounds showed a similar or a little lower bi