71855-43-1

Basic information

• Product Name: methyl 3-hydroxy-D-tyrosinate
• CAS NO: 71855-43-1
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.2145
• Mol File: 71855-43-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 384.4°C at 760 mmHg
• Flash Point: 186.3°C
• Density: 1.322g/cm³
• Vapor Pressure: 1.86E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: methyl 3-hydroxy-D-tyrosinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxy-D-tyrosinate(71855-43-1)
• EPA Substance Registry System: methyl 3-hydroxy-D-tyrosinate(71855-43-1)

Safety Data

• Hazardous Substances Data: 71855-43-1(Hazardous Substances Data)

Upstream product

• 7101-51-1 (+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine 
• 67-56-1 methanol 
• 63-84-3 dopa 
• 5796-17-8 D-Dopa 

Downstream Products

• 118068-19-2 (1R,3R)-6,7-Dihydroxy-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester 
• 59-92-7 levodopa 
• 7101-51-1 L-DOPA methyl ester 
• 59686-54-3 methyl N-(tert-butyloxycarbonyl)-3,4-bis(hydroxy)phenylalanine carboxylate 
• 118068-20-5 (1R,3R)-6,7-Dihydroxy-1-(3,4,5-trimethoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester 
• 118139-59-6 (6R,8R)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxylic acid methyl ester 
• 118068-14-7 (6R,8R)-6-(3,4,5-Trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxylic acid amide 
• 118067-89-3 (3aR,11R)-11-(3,4,5-Trimethoxy-phenyl)-3,3a,4,7,8,11-hexahydro-2,6,9-trioxa-1-thia-11a-aza-cyclopenta[b]anthracene 1-oxide 
• 128050-00-0 (4R,11aR)-4-(3,4,5-Trimethoxy-phenyl)-1,4,7,8,11,11a-hexahydro-2,6,9-trioxa-3a-aza-cyclopenta[b]anthracen-3-one 

Relevant articles and documents

Efficient and practical protection of the catechol residue of 3,4-dihydroxy-phenylalanine (DOPA) derivative as acetonide

The acetonide formation of 3,4-dihydroxyphenylalanine (DOPA) derivative was realized under efficient and practical reaction conditions: the reaction of the methyl ester of DOPA in acetone-i-PrOH in the presence of 5 mol% of TsOH afforded the catechol side chain protected DOPA as an acetonide in quantitative yield; the workup procedure is a simple evaporation of the solvents. This methodology allows an access to the reaction in large scale. Georg Thieme Verlag Stuttgart.

Derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition

The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphocyte by src homology region 2(SH2) domain of T lymphocyte (lck), so that they can be used for the treatment, prevention and/or diagnosis of graft rejection, autoimmune diseases, inflammatory diseases, etc.

Design and synthesis of small chemical inhibitors containing different scaffolds for lck SH2 domain

On the basis of the structure of (R)-rosmarinic acid, a series of small chemical compounds with a different scaffold was synthesized as inhibitors for lck SH2 domain. From ELISA results, most of all chemical compounds showed a similar or a little lower bi