1160608-92-3

Upstream product

• 1160608-91-2 6-chloro-N₄-(4-trifluoromethyl-phenyl)-pyrimidine-4,5-diamine hydrochloride 
• 61875-53-4 2,6-dichlorophenylacetylchloride 
• 882769-94-0 6-chloro-N⁽⁴⁾-(4-trifluoromethylphenyl)pyrimidine-4,5-diamine 
• 455-14-1 4-trifluoromethylphenylamine 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 

Downstream Products

• 1160606-90-5 JNJ-39729209 
• 1268267-61-3 C₁₉H₁₃Cl₂F₃N₄OS 

Relevant academic research and scientific papers

Scale-up synthesis of a TRPV1 antagonist featuring a facile thiazolo[5,4-d]pyrimidine formation

An efficient and practical synthesis of a TRPV1 inhibitor bearing a thiazolo[5,4-d]pyrimidine core was developed. The initial synthesis was modified to facilitate acylation of 5-aminopyrimidine and subsequent thiazole formation. The synthesis features an efficient two-pot, five-step process for the construction of the thiazolo[5,4-d]pyrimidine ring. The new route is concise, chromatography-free, and amenable to large-scale preparation.

Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1

Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.