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(R)-1-(1-hydroxybutan-2-yl)-3-phenylurea is a chiral compound belonging to the class of urea derivatives. It features a hydroxybutyl group attached to the nitrogen atom of the urea moiety, with the hydroxyl group positioned at the first carbon of the butyl chain. The phenyl group is attached to the other nitrogen atom of the urea, creating a structure that is asymmetric due to the presence of the chiral center at the butyl chain. (R)-1-(1-hydroxybutan-2-yl)-3-phenylurea is significant in organic chemistry and pharmaceutical research, as its stereochemistry can influence its biological activity and interactions with enzymes or receptors. The specific configuration of the molecule, with the hydroxyl group on the right side when viewed from the nitrogen atom, is denoted by the "R" prefix, indicating that it is the right-handed enantiomer in the Cahn-Ingold-Prelog priority rules.

6189-18-0

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6189-18-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6189-18-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,8 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6189-18:
(6*6)+(5*1)+(4*8)+(3*9)+(2*1)+(1*8)=110
110 % 10 = 0
So 6189-18-0 is a valid CAS Registry Number.

6189-18-0Relevant academic research and scientific papers

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

Kim, Taek Hyeon,Lee, Gue-Jae,Cha, Mi-Hyun

, p. 2753 - 2758 (1999)

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.

Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity

Dobrikov, Georgi M.,Valcheva, Violeta,Nikolova, Yana,Ugrinova, Iva,Pasheva, Evdokia,Dimitrov, Vladimir

supporting information, p. 468 - 473 (2013/07/25)

The synthesis of 22 structurally diverse urea, thiourea and acylthiourea derivatives containing the (R)-2-amino-1-butanol motif has been performed. The evaluation of their in vitro activity against Mycobacterium tuberculosis (H 37Rv and strain

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