6191-70-4

Usage

Uses

Used in Synthetic Chemistry:
Phosphonium, [4-(acetyloxy)butyl]triphenyl-, bromide is used as a reactant in the synthetic preparation of labeled DNA samples. Its unique reactivity allows for the efficient incorporation of labels into DNA, which can be crucial for various research and diagnostic applications.
Used in Biotechnology and Molecular Biology:
In the biotechnology and molecular biology industries, Phosphonium, [4-(acetyloxy)butyl]triphenyl-, bromide is used as a reagent for the modification and labeling of biomolecules, particularly nucleic acids. This enables researchers to track and study the behavior of these molecules in various biological processes, contributing to a better understanding of genetic mechanisms and the development of novel therapeutic strategies.
Used in Drug Delivery Systems:
Phosphonium, [4-(acetyloxy)butyl]triphenyl-, bromide may also be utilized in the development of drug delivery systems, where its unique properties can be harnessed to improve the targeting, release, and overall efficacy of therapeutic agents. This application can be particularly beneficial in the design of targeted drug delivery systems for cancer treatment and other diseases.

Upstream product

• 4753-59-7 4-Bromobutyl acetate 
• 603-35-0 triphenylphosphine 
• 7333-63-3 4-bromobutylphosphonium bromide 
• 127-09-3 sodium acetate 

Downstream Products

• 854001-13-1 Acetic acid (Z)-5-(4-nitro-phenyl)-pent-4-enyl ester 
• 111088-45-0 Bis-[3-(5-acetoxy-pentyl)-4-methoxy-phenyl]-iodonium; bromide 
• 111088-52-9 3'-(5-acetoxypentyl)-3,5-diiodo-N-(trifluoroacetyl)-O-methyl-L-thyronine methyl ester 
• 111088-06-3 3'-(5-acetoxypentyl)-3,5-diiodo-N-(trifluoroacetyl)-L-thyronine 
• 111088-38-1 5-(2-methoxyphenyl)pentyl acetate 
• 80645-41-6 acetyl-1 hydroxy-4 butylidenetriphenylphosphorane 
• 80645-38-1 acetoxy-4 acetyl-1 butylidenetriphenylphosphorane 
• 64172-10-7 chlorure d'hydroxy-4 butyltriphenylphosphonium 
• 80645-42-7 bromure de furoyloxy-4 butyltriphenylphosphonium 

Relevant academic research and scientific papers

Synthesis of hydroxy-γ-sanshool

Hydroxy-γ-sanshool was prepared with 19.5% overall yield through eight steps. Wittig reactions of ylides with ethyl 4-oxobut-2-enoate as well as (2E,4E)-hex-2,4-dienal were key steps to construct a carbon skeleton. The 2E,4Z-isomer in ethyl 8-hydroxyocta-

Synthesis of hydroxy-α-sanshool

Hydroxy-α-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2E,4E-hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E-isomer with catalysis by I2 and 2E,6Z,8E,10E-dodecatetraenoic acid was crystallized from a solution in 1% ethyl acetate in n-hexane.

COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE AND DEPROTECTION OF SURFACE-BOUND OLIGONUCLEOTIDES

Embodiments of the present disclosure relate to methods of preparation of templates for polynucleotide sequencing. In particular, the disclosure relates to linearization of clustered polynucleotides in preparation for sequencing by cleavage of one or more first strands of double-stranded polynucleotides immobilized on a solid support by a transition metal complex, for example, a palladium complex or a nickel complex. Further disclosure relate to linearization of clustered polynucleotides by cleaving one or more second strands of double double-stranded polynucleotides immobilized on a solid support comprising azobenzene linker by Na2S2O4. Nucleotides and oligonucleotides comprising a 3′ phosphate moiety blocking group, and methods of removing the same using a fluoride reagent are also disclosed.

Method for pairwise sequencing of target polynucleotides

The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template.

Preparation of Templates for Nucleic Acid Sequencing

The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5′ end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.

Thyroid Hormone Analogues. Synthesis of 3'-Substituted 3,5-Diiodo-L-thyronines and Quantitative Structure-Activity Studies of in Vivo Thyromimetic Activities in Rat Liver and Heart

Twenty-nine 3'-substituted derivatives of the thyroid hormone 3,3',5-triiodo-L-thyronine (T3) have been synthesized by using established methods and by new route involving manipulation of a 3'-formyl intermediate.In vitro hormone receptor binding (to intact nuclei) and in vivo thyromimetic activity (induction of mitochondrial 3-phosphoglycerate oxidoreductase, GPDH) were measured in rat liver and heart for these new analogues and for the 18 previously reported 3'-substituted 3,5-diiodo-L-thyronines.Analysis of the binding data using theoretical conformational and quantitative structure-affinity methods implies that the 3'-substituent recognition site on the thyroid hormone receptor is hydrophobic and limited in depth to the length of the natural iodo substituent, but has sufficient width to accomodate a phenyl or cyclohexyl group.Receptor binding is reduced by approximately 10-fold in 3'-acyl derivatives which form strong intramolecular acceptor hydrogen bonds with the ajacent 4'-hydroxyl.The compounds studied showed no differences in their relative affinities for heart and liver nuclei, suggesting that receptors in these tissues are similar.However, the relationships between thyromimetic activity (induction of GPDH) and nuclear binding showed some tissue differences.A high correlation between activity and binding is observed for full agonists in the heart, but an equally significant correlation for the liver data is only seen when 3'-substituent bulk (molar reactivity) is included in the analysis.These results suggest the possibility that differential tissue penetration or access to receptors may occur in vivo.

ACYLOXYALKYLIDENEPHOSPHORANES-II; ETUDE DES Ω-ACYLOXY N-BUTYLIDENETRIPHENYLPHOSPHORANES. NOUVELLE VOIE D'ACCES AUX DIHYDRO-3,4 2H-PYRANNES

ω-Acyloxy n-butylidenetriphenylphosphoranes give α-acyl n-butylidenetriphenylphosphoranes by intermolecular condensation in t-BuOH, and 3,4-dihydro-(2H)-pyrans by intramolecular condensation in toluene.The α-acyl n-butylidene phosphoranes, which are the t