61971-99-1

Upstream product

• 507-09-5 tiolacetic acid 
• 545-52-8 3α,14-dihydroxy-5β,14β-card-20(22)-enolide 
• 60124-15-4 Methanesulfonic acid (3R,5R,8R,9S,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydro-furan-3-yl)-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 10387-40-3 potassium thioacetate 
• 36010-22-7 3-epi-O-p-toluenesulfonyl-digitoxigenin 
• 71-63-6 digitoxin 
• 143-62-4 (+)-digitoxigenin 
• 1102-88-1 digitoxigenone 

Relevant academic research and scientific papers

Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs

The cardiac glycoside digitoxin, consisting of a steroid core linked to a labile trisaccharide, has been used for centuries for the treatment of congestive heart failure. The well known pharmacological effect is a result of the ability of cardiac glycosides to inhibit the Na+, K +-ATPase. Within recent years cardiac glycosides have furthermore been suggested to possess valuable anticancer activity. To mimic the labile trisaccharide of digitoxin with a stabile carbohydrate surrogate, we have used sulfur linked ethylene glycol moieties of varying length (mono-, di-, tri- or tetra-ethylene glycol), and furthermore used these linkers as handles for the synthesis of bivalent steroids. The prepared compounds were evaluated for their potencies to inhibit the Na+, K+-ATPase and for their cytotoxic effect on cancerous MCF-7 cells. A clear trend is observed in both inhibition and cytotoxic effect, where the bioactivity decreases as the size increases. The most potent Na+, K+-ATPase inhibitors are the compounds with the shortest ethylene glycol chain (Kapp 0.48 μM) and thiodigitoxigenin (Kapp 0.42 μM), which both are comparable with digitoxigenin (Kapp 0.52 μM). For the cancer cell viability assay the shortest mimics were found to have highest efficacy, with the best ligand having a monoethylene glycol unit (IC50 0.24 μM), which was slightly better than digitoxigenin (IC50 0.64 μM), while none of the novel cardiac glycoside mimics display an in vitro effect as high as digitoxin (IC50 0.02 μM).

Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

The synthesis and the binding affinities to the digitalis receptor on the Na+, K+-ATPase of a series of 3β-(aminoalkylthio digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresponding 3β-hydroxy and 3β-mercapto parent compounds.

Digitoxigenin and dihydrodigitoxigenin 3β-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders

Digitoxigenin and dihydrodigitoxigenin 3β-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.