61995-46-8Relevant academic research and scientific papers
Friedel-Crafts alkylation of indoles with trichloroacetimidates
Suzuki, Tamie,Chisholm, John D.
supporting information, p. 1325 - 1329 (2019/04/14)
Substituted indole scaffolds are often utilized in medicinal chemistry as they regularly possess significant pharmacological activity. Therefore the development of simple, inexpensive and efficient methods for alkylating the indole heterocycle continues t
Pd-catalyzed addition of boronic acids to vinylogous imines: A convenient approach to 3-sec-alkyl substituted indoles
Cao, Liang-Liang,Li, Xu-Ni,Meng, Fan-Yan,Jiang, Guo-Fang
supporting information; experimental part, p. 3873 - 3875 (2012/08/14)
A convenient approach to 3-sec-alkyl substituted indoles was developed via palladium-catalyzed addition of arylboronic acids to vinylogous imines generated in situ from sulfonylindoles under mild conditions.
Rhodium-catalyzed addition of boronic acids to vinylogous imines generated in situ from sulfonylindoles
Cao, Liang-Liang,Ye, Zhi-Shi,Jiang, Guo-Fang,Zhou, Yong-Gui
experimental part, p. 3352 - 3356 (2012/02/01)
The rhodium-catalyzed addition of arylboronic acids to vinylogous imines generated in situ from sulfonylindoles has been developed. This procedure provided a rapid approach to C-3 sec-alkyl-substituted indoles. Copyright
Nucleophilic substitution reactions of alcohols with use of montmorillonite catalysts as solid Bronsted acids
Motokura, Ken,Nakagiri, Nobuaki,Mizugaki, Tomoo,Ebitani, Kohki,Kaneda, Kiyotomi
, p. 6006 - 6015 (2008/02/10)
(Chemical Equation Presented) We have developed an environmentally benign synthetic approach to nucleophilic substitution reactions of alcohols that minimizes or eliminates the formation of byproducts, resulting in a highly atom-efficient chemical process. Proton- and metal-exchanged montmorillonites (H- and Mn+-mont) were prepared easily by treating Na +-mont with an aqueous solution of hydrogen chloride or metal salt, respectively. The H-mont possessed outstanding catalytic activity for nucleophilic substitution reactions of a variety of alcohols with anilines, because the unique acidity of the H-mont catalyst effectively prevents the neutralization by the basic anilines. In addition, amides, indoles, 1,3-dicarbonyl compounds, and allylsilane act as nucleophiles for the H-mont-catalyzed substitutions of alcohols, which allowed efficient formation of various C-N and C-C bonds. The solid H-mont was reusable without any appreciable loss in its catalytic activity and selectivity. Especially, an Al3+-mont showed high catalytic activity for the α-benzylation of 1,3-dicarbonyl compounds with primary alcohols due to cooperative catalysis between a protonic acid site and a Lewis acidic Al3+ species in its interlayer spaces.
