6200-59-5

Usage

Uses

Used in Medicinal Chemistry:
Imidazo[1,2-a]pyridine-3-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows it to be a promising candidate in medicinal chemistry, particularly for the creation of compounds with specific biological activities.
Used in Drug Development:
In the pharmaceutical industry, Imidazo[1,2-a]pyridine-3-carbonitrile is utilized as a building block for designing and developing novel therapeutic agents. Its incorporation into drug molecules can enhance their pharmacological profiles, making it an essential component in the advancement of medicinal treatments.
Used in Chemical Research:
Imidazo[1,2-a]pyridine-3-carbonitrile serves as a subject of interest in chemical research, where its properties and reactivity are studied to understand its behavior and potential applications better. This research can lead to the discovery of new reactions or processes that involve Imidazo[1,2-a]pyridine-3-carbonitrile, expanding its utility in various chemical applications.

InChI:InChI=1/C8H5N3/c9-5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6H

Upstream product

• 274-76-0 imidazo[1,2-a]pyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 504-29-0 2-aminopyridine 
• 57040-75-2 N,N-dimethyl-N'-pyridin-2-yl-formamidine 
• 106-96-7 propargyl bromide 
• 117459-95-7 N-(prop-2-yn-1-yl)pyridin-2-amine 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 

Relevant academic research and scientific papers

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

Convenient two-step one-pot synthesis of 3-substituted imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines

Abstract: A convenient and novel two-step one-pot method for the synthesis of 3-substituted imidazo[1,2-a]pyridines and 3-substituted imidazo[1,2-b]pyridazines was developed through the reaction of heterocyclic amines and N,?N-dimethylformamide dimethyl a

A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines

The Sandmeyer reaction of differently C-2 substituted N-(prop-2-yn-1- ylamino)pyridines is an efficient, mild, new and practical method for the stereospecific synthesis of (E)-exo-halomethylene bicyclic pyridones bearing the imidazo[1,2-a]pyridine heteroc