62001-47-2Relevant academic research and scientific papers
RSK2 benzo triazole derivatives as inhibitors of synthesis and use
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Paragraph 0087-0089, (2016/10/07)
The invention relates to synthesis of a benzotriazol derivative and its application, specifically to a compound as shown in the following formula II, a pharmaceutical composition containing the compound as shown in the formula II and an application of the compound in preparation of drugs for treating or preventing RSK2-mediated diseases.
Synthesis and biological activities of Novel Arylazopyrazolones substituted with Thiazolyhydrazone
Shah, Purvesh J.
, p. 57 - 61 (2014/03/21)
The 4-(1H)-benzotriazoyl methyl amino benzoate 3 was prepared by Mannich reaction of benzotriazole 1, ethyl-paminobenzoate 2 and formaldehyde. The prepared compound 3 then react with hydrazine hydrate results in the 4-(1H)-benzotriazoyl methyl amino benzo
The preparation of functionalized amines and amides using benzotriazole derivatives and organozinc reagents
Katritzky, Alan R.,Strah, Sonja,Belyakov, Sergei A.
, p. 7167 - 7178 (2007/10/03)
Secondary and tertiary amines 6 are conveniently prepared in good yields by reacting organozinc halides with adducts 4, which are derived from the corresponding amines, aldehydes and benzotriazole. The use of organozinc reagents enables the introduction of nitro, cyano or ester functionalities into amine mainframes. This methodology was also used to prepare functionalized amides 8.
