210158-24-0Relevant articles and documents
Reductive N-Arylethylation of Aromatic Amines and N-Heterocycles with Enol Ethers
V?gerl, Katharina,Ong, Duc Nghia,Bracher, Franz
, p. 1323 - 1330 (2017/12/26)
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
The preparation of functionalized amines and amides using benzotriazole derivatives and organozinc reagents
Katritzky, Alan R.,Strah, Sonja,Belyakov, Sergei A.
, p. 7167 - 7178 (2007/10/03)
Secondary and tertiary amines 6 are conveniently prepared in good yields by reacting organozinc halides with adducts 4, which are derived from the corresponding amines, aldehydes and benzotriazole. The use of organozinc reagents enables the introduction of nitro, cyano or ester functionalities into amine mainframes. This methodology was also used to prepare functionalized amides 8.
Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogues of cetaben
Albright,DeVries,Largis,Miner,Reich,Schaffer,Shepherd,Upeslacis
, p. 1378 - 1393 (2007/10/02)
The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro
