62012-79-7

Basic information

• Product Name: [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)
• CAS NO: 62012-79-7
• Molecular Formula: C₁₆H₂₆N₂O₁₅P₂
• Molecular Weight: 548.3296
• Mol File: 62012-79-7.mol
• Article Data: 15

Chemical Properties

• Density: 1.78g/cm³
• Refractive Index: 1.625
• CAS DataBase Reference: [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)(62012-79-7)
• EPA Substance Registry System: [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)(62012-79-7)

Safety Data

• Hazardous Substances Data: 62012-79-7(Hazardous Substances Data)

Upstream product

• 365-07-1 thymidine 5'-phosphate 
• 59-56-3 α-D-glucopyranosyl-1-phosphate 
• 16752-71-9 thymidine diphosphate 4-keto-6-deoxy-α-D-glucose 
• 365-08-2 dTTP 
• 59373-11-4 O^5'-(hydroxy-imidazol-1-yl-phosphinoyl)-thymidine 
• 2196-62-5 thymidine 5'-(α-D-glucopyranosyl diphosphate) 
• 24960-12-1 dTDP-D-fucopyranose 
• 16562-59-7 β-L-Fucopyranosyl phosphate 
• 6087-46-3 methyl 2,3,4-tri-O-acetyl-6-chloro-6-deoxy-α-D-glucopyranoside 
• 19940-17-1 methyl 2,3,4-tri-O-acetyl-6-deoxy-α-D-glucopyranoside 
• 120449-27-6 dibenzyl-(2,3,4-tri-O-benzyl-6-deoxy-α-D-glucopyranosyl) phosphate 
• 289901-75-3 ethyl 2,3,4-tri-O-benzoyl-6-deoxy-1-thio-β-D-glucopyranoside 
• 289901-76-4 ethyl 2,3,4-tri-O-benzyl-6-deoxy-1-thio-β-D-glucopyranoside 
• 4144-87-0 methyl 6-chloro-6-deoxy-α-D-glucopyranoside 

Relevant articles and documents

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses

(Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.

One-pot four-enzyme synthesis of thymidinediphosphate-l-rhamnose

A new, robust one-pot four-enzyme synthetic method was developed for thymidinediphosphate-l-rhamnose starting from d-glucose-1-phosphate. The enzymes, Glc-1-P thymidylyltransferase, dTDP-Glc-4,6-dehydratase, dTDP-4-keto-6-deoxy-Glc-3,5-epimerase and dTDP-4-keto-Rha reductase were derived from Streptococcus pneumonia serotype 23F, expressed in Escherichia coli, and studied in detail to provide the first direct evidence for their functions.

Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin

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