62019-56-1

Usage

Uses

Used in Chemical Industry:
5-Thiazolecarboxylic acid, 2,4-dichlorois used as a chemical intermediate for the synthesis of various compounds. Its unique structure and properties make it a valuable building block in the development of new chemical products.
Used in Pharmaceutical Industry:
5-Thiazolecarboxylic acid, 2,4-dichlorois used as a starting material for the development of new pharmaceutical compounds. Its potential applications in drug discovery and synthesis can lead to the creation of novel therapeutic agents.
Used in Research and Development:
5-Thiazolecarboxylic acid, 2,4-dichlorois used as a research compound for studying the properties and reactivity of thiazolecarboxylic acids and their derivatives. This can help in understanding their potential applications and limitations in various fields.

InChI:InChI=1/C4HCl2NO2S/c5-2-1(3(8)9)10-4(6)7-2/h(H,8,9)

Upstream product

• 124-38-9 carbon dioxide 
• 4175-76-2 2,4-dichlorothiazole 
• 92972-48-0 2,4-dichlorothiazole-5-carboxaldehyde 

Downstream Products

• 105315-48-8 2,4-dichloro-5-(trifluoromethyl)thiazole 
• 861708-66-9 methyl 2,4-dichlorothiazole-5-carboxylate 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS, AND METHODS

The present disclosure relates generally to compounds of formula (I) or a pharmaceutically acceptable salt, prodrug, deuterated analog, tautomer, stereoisomer, or mixture of stereoisomers thereof and their use as LRRK2 inhibitors.

INSECTICIDALLY ACTIVE THIAZOLE DERIVATIVES

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared in a manner known per se.

Novel insecticides

Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared in a manner known per se.

NOVEL INSECTICIDES

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared in a manner known per se.

Novel chemical compounds

This invention relates to newly identified compounds for inhibiting hYAK3 and/or CK2 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 and/or CK2 proteins.

Azoles. Part 8. Metallation and Bromine -> Lithium Exchange Reactions of Polyhalogenothiazoles

2,4-Dichloro- and 2,4-dibromo-thiazole were deprotonated at position-5 with LiN(iPr)2 in THF at -78 deg C and the resulting lithium compound was quenched with various reagents, to yield various trisubstituted thiazoles. 2,5-Dibromo-4-chlorothiazole reacted with n-butyllithium in THF at -78 deg C at position-5 and the resulting lithium derivative gave 2-bromo-4-chloro-5-substituted thiazoles when quenched with the appropriate reagent.Both the 2- and 5-bromine-atoms were reactive in diethyl ether. 2,5-Dibromothiazole failed to deprotonate at position-4 under various reaction conditions, whereas treatment of 2,4,5-tribromothiazole with 1 mole equivalent of n-butyllithium in THF at -90 deg C, followed by addition of dimethyl disulfide after 30 min, gave a high yield of the 2,5-bis(methylthio)-compound.The tribromo-compound was also treated with 1 mole equivalent of n-butyllithium or methyllithium under various reaction conditions and the products formed after hydrolysis were analysed by 1H NMR spectroscopy.The 5-bromine-atom is the most reactive and greater selectivity is obtained with methyllithium.