195510-33-9

Upstream product

• 189562-46-7 (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester 
• 313468-89-2 (2S, 3S)-3-N,N-dibenzylamino-2-acetyloxy-4-phenylbutyronitrile 
• 118970-36-8 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile 
• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 

Downstream Products

• 62023-63-6 (2R,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 859403-74-0 (2R,3S)-3-Dibenzylamino-2-hydroxy-N-(2-morpholin-4-yl-ethyl)-4-phenyl-butyramide 
• 859403-76-2 (2R,3S)-3-Dibenzylamino-2-hydroxy-N-isopropyl-4-phenyl-butyramide 
• 859403-80-8 (2R,3S)-3-amino-N-benzyl-2-hydroxy-4-phenylbutanamide 
• 859403-99-9 7-Methyl-8-oxo-2,3-dihydro-8H-1,4,5-trioxa-anthracene-6-carboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-2-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-amide 
• 859403-95-5 7-Methyl-8-oxo-2,3-dihydro-8H-1,4,5-trioxa-anthracene-6-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-phenethylcarbamoyl-ethyl)-amide 
• 859403-91-1 7-Methyl-8-oxo-2,3-dihydro-8H-1,4,5-trioxa-anthracene-6-carboxylic acid ((1S,2R)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide 
• 859403-97-7 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-2-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-amide 
• 859404-03-8 7-Methyl-8-oxo-2,3-dihydro-8H-1,4,5-trioxa-anthracene-6-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-isopropylcarbamoyl-ethyl)-amide 
• 859404-07-2 7-Methyl-8-oxo-2,3-dihydro-8H-1,4,5-trioxa-anthracene-6-carboxylic acid ((1S,2R)-1-benzyl-2-carbamoyl-2-hydroxy-ethyl)-amide 
• 859403-93-3 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-phenethylcarbamoyl-ethyl)-amide 
• 859403-89-7 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide 
• 859404-09-4 3-Ethyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-carbamoyl-2-hydroxy-ethyl)-amide 
• 859404-01-6 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-isopropylcarbamoyl-ethyl)-amide 

Relevant academic research and scientific papers

Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives

The present invention relates to a process for reacting α-aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active α-aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.

Process for producing norstatin derivatives

This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated procedure, and can be practiced on a commercial scale. This inventi

Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.