136354-01-3Relevant articles and documents
A convenient method for synthesis of optically active β-hydroxyamines from primary amines through enecarbamates as key intermediates
Matsumura, Yoshihiro,Ohishi, Takahiro,Sonoda, Chihiro,Maki, Toshihide,Watanabe, Mitsuaki
, p. 4579 - 4592 (2007/10/03)
This report describes a new method to prepare optically active β-hydroxamines starting from primary amines. The method consists of a transformation of N-methoxycarbonylated primary amines to the corresponding enecarbamates utilizing electrochemical oxidat
ELECTROCHEMICAL AND PHOTOCHEMICAL PREPARATION OF N-ACYLATED α-METHOXY-PHENETHYLAMINE. FAILURE TO CONVERSION INTO PHENYLALANINE.
Callens, R.,Anteunis, M. J. O.,Witte, M. De
, p. 619 - 622 (2007/10/02)
Anodic oxidation of N-methoxycarbonyl phenethylamine in MeOH at pH 9 proceeds quantitatively although only 45percent conversion can be reached in a simple undivided electrocell as the result of the formation of an obstructing precipitate.Treatment of several N-acyl-α-methoxy derivatives with cyanide results in elimination instead of substitution.The preparation of Phe from the above-mentioned synthons therefore was unsuccessfull.