136354-01-3Relevant academic research and scientific papers
A convenient method for synthesis of optically active β-hydroxyamines from primary amines through enecarbamates as key intermediates
Matsumura, Yoshihiro,Ohishi, Takahiro,Sonoda, Chihiro,Maki, Toshihide,Watanabe, Mitsuaki
, p. 4579 - 4592 (2007/10/03)
This report describes a new method to prepare optically active β-hydroxamines starting from primary amines. The method consists of a transformation of N-methoxycarbonylated primary amines to the corresponding enecarbamates utilizing electrochemical oxidat
Preparation of acyclic N-acyl-N,O-acetals by decarboxylation of N-protected α-amino acids and studies of asymmetric amidoalkylation with trimethylsilyl cyanide
Harding,Liu,Farrar,Coleman,Tansey
, p. 1409 - 1417 (2007/10/02)
Oxidative decarboxylation of N-acyl-α-amino acids with lead tetraacetate followed by treatment with methanol provides a facile method for preparation of acyclic N-acyl-N,O-acetals, which can be used in asymmetric α-amidoalkylation reactions using trimethylsilyl cyanide as nucleophile.
ELECTROCHEMICAL AND PHOTOCHEMICAL PREPARATION OF N-ACYLATED α-METHOXY-PHENETHYLAMINE. FAILURE TO CONVERSION INTO PHENYLALANINE.
Callens, R.,Anteunis, M. J. O.,Witte, M. De
, p. 619 - 622 (2007/10/02)
Anodic oxidation of N-methoxycarbonyl phenethylamine in MeOH at pH 9 proceeds quantitatively although only 45percent conversion can be reached in a simple undivided electrocell as the result of the formation of an obstructing precipitate.Treatment of several N-acyl-α-methoxy derivatives with cyanide results in elimination instead of substitution.The preparation of Phe from the above-mentioned synthons therefore was unsuccessfull.
