62033-58-3

Upstream product

• 79445-45-7 3-(3,4-Dimethoxyphenyl)pyridine 
• 626-55-1 3-Bromopyridine 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 

Downstream Products

• 61832-52-8 3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide 
• 62033-50-5 3-(3,4-dihydroxyphenyl)-N-n-propylpiperidine 
• 62033-61-8 3-(3,4-dimethoxyphenyl)-1-propylpiperidine 
• 62033-63-0 N-(β-phenylethyl)-3-(3',4'-dimethoxyphenyl)-piperidine 
• 62033-57-2 3-(3,4-dimethoxy-phenyl)-1-methyl-piperidine; hydrochloride 
• 62033-60-7 N-acetyl-3-(3',4'-dimethoxyphenyl)-piperidine 

Relevant academic research and scientific papers

3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.

3-(3',4'-Disubstituted) phenyl piperidines

Novel phenyl piperidines of the formula STR1 wherein X is selected from the group consisting of hydrogen and acyl of an aliphatic carboxylic acid of 2 to 6 carbon atoms and R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkenyl o