62044-21-7

Upstream product

• 62044-37-5 4-cyanophenylacetic acid chloride 
• 133-13-1 ethyl diethyl malonate 
• 61540-30-5 3-oxohexanoic acid tert-butyl ester 
• 3058-39-7 4-iodobenzonitrile 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 17201-43-3 4-cyanobenzyl bromide 
• 156567-57-6 propylzinc bromide 
• 59824-23-6 4-(2-oxo-2-phenylethyl)benzonitrile 
• 2432-51-1 ethylthioacetic acid methyl ester 
• 1387574-33-5 octyl p-cyanophenylmethyl ketone 
• 5462-71-5 4-cyanophenylacetic acid 

Relevant academic research and scientific papers

Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN2 Pincer Ligand Complex

An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp3-carbon fragments. The method, which relies on the application of nickel complexed with an NN2-type pincer ligand and a controlled release of CO gas from a solid precursor, works well with a range of benzylic bromides. Mechanistic studies suggest the intermediacy of carbon-centered radicals.

Copper-catalyzed coupling of aryl iodides and tert-butyl keto esters: Efficient access to α-aryl ketones and α-arylacetic acid tert-butyl esters

CuI/trans-4-hydroxy-l-proline catalyzed coupling of aryl iodides with tert-butyl keto esters proceeded smoothly at 40 °C in DMF, providing α-aryl ketones after acid-promoted deprotection and decarboxylation of tert-butyl ester group. While CuI/2-picolinic acid catalyzed coupling of aryl iodides with tert-butyl acetoacetate at 70 °C in dioxane delivered α-arylacetic acid tert-butyl esters upon spontaneous deacylation. A wide range of functional groups, such as acetyl, methoxy, nitrile, nitro, bromo, and chloro were compatible with the reaction conditions.

Rhodium-catalyzed acyl-transfer reaction between benzyl ketones and thioesters: Synthesis of unsymmetric ketones by ketone CO-C bond cleavage and intermolecular rearrangement

In the presence of catalytic amounts of RhH(CO)(PPh3) 3 and 1,2-bis(diphenylphosphino)benzene (dppBz), acyl groups were transferred between benzyl ketones and thioesters/aryl esters. The rhodium complex catalyzed the cleavage of keto

Formation of a Novel Acyl Anion Equivalent by the Electroreduction of Oxazolinium Salts

Electroreduction of oxazolinium salts synthesized from the corresponding carboxylic acids gave a novel acyl anion equivalent (AAE).The reaction of these AAEs with electrophiles afforded the corresponding aldehydes or ketones in good yields.